Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040773899> ?p ?o ?g. }
- W2040773899 endingPage "1779" @default.
- W2040773899 startingPage "1767" @default.
- W2040773899 abstract "Amyotrophic lateral sclerosis (ALS) is a devastating degenerative disease characterized by progressive loss of motor neurons in the motor cortex, brainstem, and spinal cord. Although defined as a motor disorder, ALS can arise concurrently with frontotemporal lobal dementia (FTLD). ALS begins focally but disseminates to cause paralysis and death. About 10% of ALS cases are caused by gene mutations, and more than 40 ALS-associated genes have been identified. While important questions about the biology of this disease remain unanswered, investigations of ALS genes have delineated pathogenic roles for (a) perturbations in protein stability and degradation, (b) altered homeostasis of critical RNA- and DNA-binding proteins, (c) impaired cytoskeleton function, and (d) non-neuronal cells as modifiers of the ALS phenotype. The rapidity of progress in ALS genetics and the subsequent acquisition of insights into the molecular biology of these genes provide grounds for optimism that meaningful therapies for ALS are attainable." @default.
- W2040773899 created "2016-06-24" @default.
- W2040773899 creator A5005669098 @default.
- W2040773899 creator A5025571618 @default.
- W2040773899 creator A5051922970 @default.
- W2040773899 date "2015-05-01" @default.
- W2040773899 modified "2023-10-11" @default.
- W2040773899 title "Emerging mechanisms of molecular pathology in ALS" @default.
- W2040773899 cites W1503916499 @default.
- W2040773899 cites W1619082318 @default.
- W2040773899 cites W1787406445 @default.
- W2040773899 cites W1910247150 @default.
- W2040773899 cites W1965286266 @default.
- W2040773899 cites W1965366097 @default.
- W2040773899 cites W1966202673 @default.
- W2040773899 cites W1966682365 @default.
- W2040773899 cites W1967851074 @default.
- W2040773899 cites W1967932847 @default.
- W2040773899 cites W1974448552 @default.
- W2040773899 cites W1974961961 @default.
- W2040773899 cites W1977649097 @default.
- W2040773899 cites W1981329326 @default.
- W2040773899 cites W1982356267 @default.
- W2040773899 cites W1984538960 @default.
- W2040773899 cites W1984614964 @default.
- W2040773899 cites W1984979116 @default.
- W2040773899 cites W1988849173 @default.
- W2040773899 cites W1993064034 @default.
- W2040773899 cites W1993354361 @default.
- W2040773899 cites W1995061803 @default.
- W2040773899 cites W1996024251 @default.
- W2040773899 cites W1999638129 @default.
- W2040773899 cites W2003618511 @default.
- W2040773899 cites W2004850573 @default.
- W2040773899 cites W2008563656 @default.
- W2040773899 cites W2008760810 @default.
- W2040773899 cites W2011481695 @default.
- W2040773899 cites W2012016770 @default.
- W2040773899 cites W2012850029 @default.
- W2040773899 cites W2013131112 @default.
- W2040773899 cites W2013846239 @default.
- W2040773899 cites W2017539935 @default.
- W2040773899 cites W2019129236 @default.
- W2040773899 cites W2020914812 @default.
- W2040773899 cites W2021168188 @default.
- W2040773899 cites W2025629415 @default.
- W2040773899 cites W2027053612 @default.
- W2040773899 cites W2027433665 @default.
- W2040773899 cites W2027824376 @default.
- W2040773899 cites W2028198537 @default.
- W2040773899 cites W2029225256 @default.
- W2040773899 cites W2030073535 @default.
- W2040773899 cites W2030893485 @default.
- W2040773899 cites W2032107666 @default.
- W2040773899 cites W2032162800 @default.
- W2040773899 cites W2033158384 @default.
- W2040773899 cites W2041964860 @default.
- W2040773899 cites W2043132580 @default.
- W2040773899 cites W2043921345 @default.
- W2040773899 cites W2050626075 @default.
- W2040773899 cites W2050671527 @default.
- W2040773899 cites W2051470096 @default.
- W2040773899 cites W2051924686 @default.
- W2040773899 cites W2054068057 @default.
- W2040773899 cites W2054542675 @default.
- W2040773899 cites W2059355164 @default.
- W2040773899 cites W2060076138 @default.
- W2040773899 cites W2061954667 @default.
- W2040773899 cites W2063996210 @default.
- W2040773899 cites W2064526870 @default.
- W2040773899 cites W2066002405 @default.
- W2040773899 cites W2067250059 @default.
- W2040773899 cites W2068147651 @default.
- W2040773899 cites W2069171272 @default.
- W2040773899 cites W2072545392 @default.
- W2040773899 cites W2072978915 @default.
- W2040773899 cites W2072981065 @default.
- W2040773899 cites W2074726646 @default.
- W2040773899 cites W2075186362 @default.
- W2040773899 cites W2075437040 @default.
- W2040773899 cites W2075588816 @default.
- W2040773899 cites W2079867419 @default.
- W2040773899 cites W2080757088 @default.
- W2040773899 cites W2084942172 @default.
- W2040773899 cites W2086914876 @default.
- W2040773899 cites W2088204428 @default.
- W2040773899 cites W2088483634 @default.
- W2040773899 cites W2095362003 @default.
- W2040773899 cites W2095685454 @default.
- W2040773899 cites W2096386031 @default.
- W2040773899 cites W2097965815 @default.
- W2040773899 cites W2104442834 @default.
- W2040773899 cites W2105028572 @default.
- W2040773899 cites W2105897360 @default.
- W2040773899 cites W2107315373 @default.
- W2040773899 cites W2107660300 @default.
- W2040773899 cites W2107768418 @default.
- W2040773899 cites W2109318055 @default.