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- W2040776957 abstract "Among p-phenylenediamine, benzidine and the analogues we previously tested, only the nitro-group containing 2-nitro-p-phenylenediamine, 3-nitro-o-phenylenediamine, 4-nitro-o-phenylenediamine and 4,4′-dinitro-2-biphenylamine caused base-pair reversion in the histidine locus of Salmonella typhimurium TA100. In order to determine the types of mutations involved, such as transversion or transition, these four nitro-group containing compounds were tested with S. typhimurium strains TA100, TA104, TA4001 and TA4006. Dose-mutagenicity relationships occurred with TA100 and TA104. However, the majority of revertants from TA100 and TA104 were insensitive to inhibition by histidine analogue, dl-1,2,4-triazole-3-alanine. These results suggested that the occurrence of histidine revertants was predominantly induced by base-pair (point) mutations and not by suppressor gene mutations. The CG–TA transition and CG–AT transversion are the major types of mutation induced by all these compounds in TA100. The TA–AT transversion also contributed to the mutagenicity of 4-nitro-o-phenylenediamine and 4,4′-dinitro-2-biphenylamine in TA104. These nitro-group containing compounds showed no mutagenicity in TA4001, but induced CG–GC transversion in TA4006." @default.
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- W2040776957 date "1997-12-01" @default.
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- W2040776957 title "Base-pair mutation caused by four nitro-group containing aromatic amines in Salmonella typhimurium TA100, TA104, TA4001 and TA4006" @default.
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- W2040776957 doi "https://doi.org/10.1016/s1383-5718(97)00161-7" @default.
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