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- W2040778912 abstract "The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% O 2 prevented the development of urethan- or 3-methykholan-threne-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisote (BHA)] were unable to prevent the inhibition of tumor development by oxygen, although BHT retained its capability to enhance tumor development in mouse lung. In visible-size tumors, oxygen did not depress DNA synthesis. Oxygen also reduced the number of pulmonary metastatk nodules after i.v. injection of mammary gland-derived carcinoma cells, but failed to inhibit growth of murine lung carcinoma or murine melanoma-derived cell lines. Rats treated with one single intratracheal instillation of 3-methylcholanthrene developed multiple lung lesions; their growth could be prevented by exposure of the animals to 40 or 70% O 2 . It is concluded that hyperoxia prevents development of transformed cells in vivo in the lung and may affect adversely the growth of selected cell lines meta-static to the lung." @default.
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- W2040778912 title "Modification of lung tumor growth by hyperoxia" @default.
- W2040778912 doi "https://doi.org/10.1093/carcin/7.9.1581" @default.
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