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- W2040778960 endingPage "103" @default.
- W2040778960 startingPage "89" @default.
- W2040778960 abstract "Autophagy is a constitutive lysosomal catabolic pathway that degrades damaged organelles and protein aggregates. Stem cells are characterized by self-renewal, pluripotency, and quiescence; their long life span, limited capacity to dilute cellular waste and spent organelles due to quiescence, along with their requirement for remodeling in order to differentiate, all suggest that they require autophagy more than other cell types. Here, we review the current literature on the role of autophagy in embryonic and adult stem cells, including hematopoietic, mesenchymal, and neuronal stem cells, highlighting the diverse and contrasting roles autophagy plays in their biology. Furthermore, we review the few studies on stem cells, lysosomal activity, and autophagy. Novel techniques to detect autophagy in primary cells are required to study autophagy in different stem cell types. These will help to elucidate the importance of autophagy in stem cells during transplantation, a promising therapeutic approach for many diseases." @default.
- W2040778960 created "2016-06-24" @default.
- W2040778960 creator A5007275918 @default.
- W2040778960 creator A5051857586 @default.
- W2040778960 creator A5086739699 @default.
- W2040778960 date "2012-06-05" @default.
- W2040778960 modified "2023-10-10" @default.
- W2040778960 title "Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging" @default.
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