FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040781661> ?p ?o ?g. }

• W2040781661 endingPage "217" @default.
• W2040781661 startingPage "213" @default.
• W2040781661 abstract "Tetrahydrobiopterin (BH(4)) lowers blood phenylalanine (Phe) in individuals with PKU who are responders, but its effects on the brain and cognition have not been explored thoroughly. We examined blood Phe, microstructural white matter integrity, and executive abilities in 12 BH(4) responders before (i.e., baseline) and after (i.e., follow-up) six months of treatment with BH(4). Compared with baseline, Phe in these responders decreased by 51% during a 4 week screening period after initiation of treatment and remained lowered by 37% over the 6 month follow-up period. Significant improvements in white matter integrity, evaluated by mean diffusivity from diffusion tensor imaging, were also found following six months of treatment. Improvements in executive abilities were not identified, although six months may have been a period too brief for changes in cognition to follow changes in the brain. To our knowledge, our study is the first to explore relationships among Phe, white matter integrity, executive abilities, and BH(4) treatment within a single study." @default.
• W2040781661 created "2016-06-24" @default.
• W2040781661 creator A5012352667 @default.
• W2040781661 creator A5019412968 @default.
• W2040781661 creator A5027896516 @default.
• W2040781661 creator A5032797754 @default.
• W2040781661 creator A5056479467 @default.
• W2040781661 creator A5058680939 @default.
• W2040781661 creator A5059281499 @default.
• W2040781661 creator A5090027581 @default.
• W2040781661 date "2013-11-01" @default.
• W2040781661 modified "2023-10-17" @default.
• W2040781661 title "White matter integrity and executive abilities following treatment with tetrahydrobiopterin (BH4) in individuals with phenylketonuria" @default.
• W2040781661 cites W1568545361 @default.
• W2040781661 cites W1979831854 @default.
• W2040781661 cites W1984655161 @default.
• W2040781661 cites W1996456247 @default.
• W2040781661 cites W1996958346 @default.
• W2040781661 cites W2000254066 @default.
• W2040781661 cites W2024230640 @default.
• W2040781661 cites W2039340892 @default.
• W2040781661 cites W2040390829 @default.
• W2040781661 cites W2042661061 @default.
• W2040781661 cites W2055667792 @default.
• W2040781661 cites W2057934986 @default.
• W2040781661 cites W2064774310 @default.
• W2040781661 cites W2078828195 @default.
• W2040781661 cites W2095332339 @default.
• W2040781661 cites W2132820737 @default.
• W2040781661 cites W2138340059 @default.
• W2040781661 doi "https://doi.org/10.1016/j.ymgme.2013.07.010" @default.
• W2040781661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3832288" @default.
• W2040781661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23928118" @default.
• W2040781661 hasPublicationYear "2013" @default.
• W2040781661 type Work @default.
• W2040781661 sameAs 2040781661 @default.
• W2040781661 citedByCount "35" @default.
• W2040781661 countsByYear W20407816612014 @default.
• W2040781661 countsByYear W20407816612015 @default.
• W2040781661 countsByYear W20407816612016 @default.
• W2040781661 countsByYear W20407816612017 @default.
• W2040781661 countsByYear W20407816612018 @default.
• W2040781661 countsByYear W20407816612019 @default.
• W2040781661 countsByYear W20407816612020 @default.
• W2040781661 countsByYear W20407816612021 @default.
• W2040781661 countsByYear W20407816612022 @default.
• W2040781661 countsByYear W20407816612023 @default.
• W2040781661 crossrefType "journal-article" @default.
• W2040781661 hasAuthorship W2040781661A5012352667 @default.
• W2040781661 hasAuthorship W2040781661A5019412968 @default.
• W2040781661 hasAuthorship W2040781661A5027896516 @default.
• W2040781661 hasAuthorship W2040781661A5032797754 @default.
• W2040781661 hasAuthorship W2040781661A5056479467 @default.
• W2040781661 hasAuthorship W2040781661A5058680939 @default.
• W2040781661 hasAuthorship W2040781661A5059281499 @default.
• W2040781661 hasAuthorship W2040781661A5090027581 @default.
• W2040781661 hasBestOaLocation W20407816612 @default.
• W2040781661 hasConcept C118552586 @default.
• W2040781661 hasConcept C126322002 @default.
• W2040781661 hasConcept C126838900 @default.
• W2040781661 hasConcept C143409427 @default.
• W2040781661 hasConcept C149550507 @default.
• W2040781661 hasConcept C15744967 @default.
• W2040781661 hasConcept C169900460 @default.
• W2040781661 hasConcept C185592680 @default.
• W2040781661 hasConcept C207009774 @default.
• W2040781661 hasConcept C2775968953 @default.
• W2040781661 hasConcept C2776145790 @default.
• W2040781661 hasConcept C2777431362 @default.
• W2040781661 hasConcept C2777622882 @default.
• W2040781661 hasConcept C2781192897 @default.
• W2040781661 hasConcept C515207424 @default.
• W2040781661 hasConcept C519581460 @default.
• W2040781661 hasConcept C55493867 @default.
• W2040781661 hasConcept C71924100 @default.
• W2040781661 hasConceptScore W2040781661C118552586 @default.
• W2040781661 hasConceptScore W2040781661C126322002 @default.
• W2040781661 hasConceptScore W2040781661C126838900 @default.
• W2040781661 hasConceptScore W2040781661C143409427 @default.
• W2040781661 hasConceptScore W2040781661C149550507 @default.
• W2040781661 hasConceptScore W2040781661C15744967 @default.
• W2040781661 hasConceptScore W2040781661C169900460 @default.
• W2040781661 hasConceptScore W2040781661C185592680 @default.
• W2040781661 hasConceptScore W2040781661C207009774 @default.
• W2040781661 hasConceptScore W2040781661C2775968953 @default.
• W2040781661 hasConceptScore W2040781661C2776145790 @default.
• W2040781661 hasConceptScore W2040781661C2777431362 @default.
• W2040781661 hasConceptScore W2040781661C2777622882 @default.
• W2040781661 hasConceptScore W2040781661C2781192897 @default.
• W2040781661 hasConceptScore W2040781661C515207424 @default.
• W2040781661 hasConceptScore W2040781661C519581460 @default.
• W2040781661 hasConceptScore W2040781661C55493867 @default.
• W2040781661 hasConceptScore W2040781661C71924100 @default.
• W2040781661 hasFunder F4320306183 @default.
• W2040781661 hasFunder F4320310557 @default.
• W2040781661 hasFunder F4320337347 @default.
• W2040781661 hasFunder F4320337364 @default.
• W2040781661 hasIssue "3" @default.

• next