FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040781774> ?p ?o ?g. }

• W2040781774 endingPage "B63" @default.
• W2040781774 startingPage "B63" @default.
• W2040781774 abstract "PROLYL-3 HYDROXYLASE EXPRESSION IN THE MOUSE KIDNEY AND DEVELOPING EMBRYO Jennifer Lennington, Roy Morello, Ming-Ming Jiang, Dustin Baldridge, Terry Bertin and Brendan Lee 1 = Department of Molecular and Human Genetics, Baylor College of Medicine, 2 = Howard Hughes Medical Institute All collagens undergo prolyl-3 hydroxylation post-translational modification. As specialized type IV collagen protomers are required for glomerular development, the purpose of this study is to examine which P3H isoforms are expressed in the developing mouse embryo, and specifically the kidney. In-situ probes were amplified from S293 cDNA. The probes were labeled with S and hybridized to 6 micron thick sections at E12.5 – P1. The kidney showed highest expression of P3H2 and P3H3 in distinct patterns from E16.5 onward. From E12.5 to E14.5, P3H3 was most prominent. P3H2 shows a glomerular specific expression pattern. In contrast, P3H3 shows highest expression in the interstitium and collecting system, but also is expressed in the central region of the glomerulus and the tubules. Other organs also have non-redundant P3H expression. P3H2 only is expressed in pre-hypertrophic chondrocytes, and dominates in skeletal muscle, heart, and lens of the eye. Only P3H3 localizes to the periventricular region of the brain. P3H3 expression is also highest in the aorta and pulmonary veins. All three P3H’s are expressed in the craniofacial mesenchyme, lung, and spine. Because of the unique expression of P3H2 and P3H3 in the kidney, dysfunction of each may lead to distinct renal phenotypes. P3H2 could lead to abnormal glomerular basement membranes. Due to its early developmental expression and more diffuse expression, P3H3 may be involved in dysplasia, sclerosis, or cystic disease. Expression of the P3H isoforms in other tissues makes it likely that absence of any one of these isoforms would lead to multiorgan involvement. Lack of P3H2 could cause chondrodysplasia and myopathy. Lack of P3H3 may lead to a vascular phenotype, such as aneurysms. Further study to define the specific role of P3H’s may lead to advances in diagnosis and management of chronic kidney disease." @default.
• W2040781774 created "2016-06-24" @default.
• W2040781774 creator A5029519208 @default.
• W2040781774 creator A5029932798 @default.
• W2040781774 creator A5032521274 @default.
• W2040781774 creator A5042694502 @default.
• W2040781774 creator A5065018867 @default.
• W2040781774 creator A5068371988 @default.
• W2040781774 date "2008-04-01" @default.
• W2040781774 modified "2023-09-25" @default.
• W2040781774 title "141: Prolyl-3 Hydroxylase Expression in the Mouse Kidney and Developing Embryo" @default.
• W2040781774 doi "https://doi.org/10.1053/j.ajkd.2008.02.149" @default.
• W2040781774 hasPublicationYear "2008" @default.
• W2040781774 type Work @default.
• W2040781774 sameAs 2040781774 @default.
• W2040781774 citedByCount "0" @default.
• W2040781774 crossrefType "journal-article" @default.
• W2040781774 hasAuthorship W2040781774A5029519208 @default.
• W2040781774 hasAuthorship W2040781774A5029932798 @default.
• W2040781774 hasAuthorship W2040781774A5032521274 @default.
• W2040781774 hasAuthorship W2040781774A5042694502 @default.
• W2040781774 hasAuthorship W2040781774A5065018867 @default.
• W2040781774 hasAuthorship W2040781774A5068371988 @default.
• W2040781774 hasConcept C104317684 @default.
• W2040781774 hasConcept C126322002 @default.
• W2040781774 hasConcept C145103041 @default.
• W2040781774 hasConcept C196843134 @default.
• W2040781774 hasConcept C2777632694 @default.
• W2040781774 hasConcept C2780091579 @default.
• W2040781774 hasConcept C54355233 @default.
• W2040781774 hasConcept C71924100 @default.
• W2040781774 hasConcept C86803240 @default.
• W2040781774 hasConcept C95444343 @default.
• W2040781774 hasConceptScore W2040781774C104317684 @default.
• W2040781774 hasConceptScore W2040781774C126322002 @default.
• W2040781774 hasConceptScore W2040781774C145103041 @default.
• W2040781774 hasConceptScore W2040781774C196843134 @default.
• W2040781774 hasConceptScore W2040781774C2777632694 @default.
• W2040781774 hasConceptScore W2040781774C2780091579 @default.
• W2040781774 hasConceptScore W2040781774C54355233 @default.
• W2040781774 hasConceptScore W2040781774C71924100 @default.
• W2040781774 hasConceptScore W2040781774C86803240 @default.
• W2040781774 hasConceptScore W2040781774C95444343 @default.
• W2040781774 hasIssue "4" @default.
• W2040781774 hasLocation W20407817741 @default.
• W2040781774 hasOpenAccess W2040781774 @default.
• W2040781774 hasPrimaryLocation W20407817741 @default.
• W2040781774 hasRelatedWork W2001399595 @default.
• W2040781774 hasRelatedWork W2028479889 @default.
• W2040781774 hasRelatedWork W2080885748 @default.
• W2040781774 hasRelatedWork W2133812223 @default.
• W2040781774 hasRelatedWork W2246182509 @default.
• W2040781774 hasRelatedWork W2336178310 @default.
• W2040781774 hasRelatedWork W2362741529 @default.
• W2040781774 hasRelatedWork W2368910447 @default.
• W2040781774 hasRelatedWork W2379886502 @default.
• W2040781774 hasRelatedWork W4283777601 @default.
• W2040781774 hasVolume "51" @default.
• W2040781774 isParatext "false" @default.
• W2040781774 isRetracted "false" @default.
• W2040781774 magId "2040781774" @default.
• W2040781774 workType "article" @default.