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• W2040782012 abstract "The oral delivery of soluble antigens induces unresponsiveness to systemic challenge that can be demonstrated as a reduced ability of tolerised T cells to support B-cell expansion and antibody production. However, it remains controversial whether previously induced oral tolerance results in suppression or priming, or has no effect on B-cell responses upon oral challenge. Using a double adoptive transfer system, we primed or tolerised T cells (independently of B cells) with a high dose of fed antigen, and examined the ability of these primed or tolerised T cells to support B-cell clonal expansion in response to orally delivered conjugated antigen. We demonstrated directly in vivo that, in contrast to orally primed T cells, transgenic T cells tolerised by feeding a high dose of antigen are incapable of providing cognate help to support B-cell clonal expansion and antibody production in response to oral challenge. This defect appears to be a result of a reduced ability of orally tolerised transgenic T cells to clonally expand and migrate to B-cell follicles after oral challenge." @default.
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• W2040782012 date "2004-06-29" @default.
• W2040782012 modified "2023-10-14" @default.
• W2040782012 title "An investigation of the ability of orally primed and tolerised T cells to help B cells upon mucosal challenge" @default.
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• W2040782012 doi "https://doi.org/10.1111/j.1365-2567.2004.01913.x" @default.
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