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• W2040782809 abstract "Inappropriate activation of the Hh signaling pathway has been implicated in the development of several types of cancers including prostate, lung, pancreas, breast, brain and skin. Present study identified the binding affinities of eight established inhibitors viz., Cyclopamine, Saridegib, Itraconazole, LDE-225, TAK-441, BMS-833923 (XL139), PF-04449913 and Vismodegib targeting SMO receptor - a candidate protein involved in hedgehog pathway and sought to identify the best amongst the established inhibitors through by molecular docking. Exelxis® BMS 833923 (XL 139) demonstrated superior binding affinity aided by MolDock scoring docking algorithm. Further BMS 833923 (XL 139) was evaluated for pharmacophoric features which revealed appreciable ligand receptor interactions." @default.
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• W2040782809 date "2014-12-31" @default.
• W2040782809 modified "2023-10-12" @default.
• W2040782809 title "Molecular docking approaches in identification of high affinity inhibitors of human SMO receptor" @default.
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• W2040782809 doi "https://doi.org/10.6026/97320630010737" @default.
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