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- W2040784207 abstract "Thyroid cancer has less avidity for iodide than normal thyroid tissue, thus limiting the use of I131 for inoperable thyroid malignancy. Methods to overcome this problem have relied primarily upon TSH either directly or indirectly (i.e., after antithyroid drug withdrawal). Frequently the response to TSH is minimal. That iodide deficiency can increase I131 uptake in normal thyroid tissue prompted an investigation of methods of iodide depletion in the preparation of thyroid cancer patients for I131 therapy. Iodine-deficient diets alone, and the use of NaCl and mercurial diuresis however were unsuccessful. Seven patients with residual thyroid cancer after thyroidectomy have been subjected to combined iodine-deficient diets and intravenous mannitol. This produced two- to three-fold increases in 24-hour uptakes in 5 of these patients. This augmentation in uptake is achieved without the stimulation of I131 release that is produced by TSH. The use of intravenous mannitol seems to be a valuable adjunct in the I131 therapy of inoperable thyroid cancer." @default.
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- W2040784207 date "1966-12-01" @default.
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- W2040784207 title "Mannitol augmentation of I131 uptake in the treatment of thyroid carcinoma" @default.
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- W2040784207 doi "https://doi.org/10.1016/0026-0495(66)90093-x" @default.
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