FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040784384> ?p ?o ?g. }

• W2040784384 endingPage "560" @default.
• W2040784384 startingPage "555" @default.
• W2040784384 abstract "Both iso-forms of the gamma-aminobutyric acid (GABA) synthesising enzyme and also the GABA degrading enzyme need pyridoxal 5'-phosphate (PP) as co-enzyme. The aim of the study was to investigate the influence of PP alone and in combination with various doses of vigabatrin (VGB) on brain GABA levels. In eight healthy subjects 300 mg/d PP and various doses of VGB (range, 1000 mg/d to 4000 mg/d) were given alone or in combination. The GABA+/creatine (Cr) signals in both occipital lobes were measured before treatment, during monotherapy with PP or VGB, and during combination of both using 1H-NMR-spectroscopy (1H-NMRS). PP alone did not change the GABA+/Cr signals. VGB alone increased the GABA+/Cr signals in both hemispheres. The combination PP and low-medium dosed VGB (1000-2000 mg/d) did not increase the GABA+/Cr signals. The effects of the combination of PP and high dosed (3000-4000 mg/d) VGB on the GABA+/Cr signals varied depending on the sequence of the drugs and dose of VGB. PP alone has no effect on the GABA+/Cr signals in healthy volunteers. The combination of PP and low-high dosed VGB had inconsistent effects on the GABA+/Cr signals compared to a VGB monotherapy because PP activates also the GABA-degrading enzyme GABA-transaminase." @default.
• W2040784384 created "2016-06-24" @default.
• W2040784384 creator A5006411265 @default.
• W2040784384 creator A5056060306 @default.
• W2040784384 creator A5075995754 @default.
• W2040784384 creator A5087584105 @default.
• W2040784384 date "2001-07-01" @default.
• W2040784384 modified "2023-09-27" @default.
• W2040784384 title "Influence of pyridoxal 5′-phosphate alone and in combination with vigabatrin on brain GABA measured by 1H-NMR-spectroscopy" @default.
• W2040784384 cites W1016727594 @default.
• W2040784384 cites W133306421 @default.
• W2040784384 cites W1964002146 @default.
• W2040784384 cites W1964948396 @default.
• W2040784384 cites W1968037117 @default.
• W2040784384 cites W1979302622 @default.
• W2040784384 cites W1981362455 @default.
• W2040784384 cites W1992701519 @default.
• W2040784384 cites W1997636328 @default.
• W2040784384 cites W1999713747 @default.
• W2040784384 cites W2003386451 @default.
• W2040784384 cites W2006283660 @default.
• W2040784384 cites W2016051090 @default.
• W2040784384 cites W2016389240 @default.
• W2040784384 cites W2018968718 @default.
• W2040784384 cites W2019657198 @default.
• W2040784384 cites W2020620163 @default.
• W2040784384 cites W2024435902 @default.
• W2040784384 cites W2040951012 @default.
• W2040784384 cites W2044514506 @default.
• W2040784384 cites W2045780974 @default.
• W2040784384 cites W2051806609 @default.
• W2040784384 cites W2060714844 @default.
• W2040784384 cites W2063079339 @default.
• W2040784384 cites W2067421308 @default.
• W2040784384 cites W2074830850 @default.
• W2040784384 cites W2082622595 @default.
• W2040784384 cites W2092246706 @default.
• W2040784384 cites W2107214822 @default.
• W2040784384 cites W2113159807 @default.
• W2040784384 cites W2118349239 @default.
• W2040784384 cites W2119596846 @default.
• W2040784384 cites W2128726781 @default.
• W2040784384 cites W2135858785 @default.
• W2040784384 cites W2158388157 @default.
• W2040784384 cites W2164410701 @default.
• W2040784384 cites W2419221807 @default.
• W2040784384 cites W625108668 @default.
• W2040784384 doi "https://doi.org/10.1016/s0361-9230(01)00565-2" @default.
• W2040784384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11543957" @default.
• W2040784384 hasPublicationYear "2001" @default.
• W2040784384 type Work @default.
• W2040784384 sameAs 2040784384 @default.
• W2040784384 citedByCount "10" @default.
• W2040784384 countsByYear W20407843842015 @default.
• W2040784384 countsByYear W20407843842019 @default.
• W2040784384 countsByYear W20407843842021 @default.
• W2040784384 crossrefType "journal-article" @default.
• W2040784384 hasAuthorship W2040784384A5006411265 @default.
• W2040784384 hasAuthorship W2040784384A5056060306 @default.
• W2040784384 hasAuthorship W2040784384A5075995754 @default.
• W2040784384 hasAuthorship W2040784384A5087584105 @default.
• W2040784384 hasConcept C126322002 @default.
• W2040784384 hasConcept C169760540 @default.
• W2040784384 hasConcept C170493617 @default.
• W2040784384 hasConcept C181199279 @default.
• W2040784384 hasConcept C185592680 @default.
• W2040784384 hasConcept C197957613 @default.
• W2040784384 hasConcept C2775858608 @default.
• W2040784384 hasConcept C2776834122 @default.
• W2040784384 hasConcept C2777421860 @default.
• W2040784384 hasConcept C2778186239 @default.
• W2040784384 hasConcept C2779896295 @default.
• W2040784384 hasConcept C2780837902 @default.
• W2040784384 hasConcept C2780859938 @default.
• W2040784384 hasConcept C55493867 @default.
• W2040784384 hasConcept C61174792 @default.
• W2040784384 hasConcept C71924100 @default.
• W2040784384 hasConcept C86803240 @default.
• W2040784384 hasConcept C9497952 @default.
• W2040784384 hasConcept C98274493 @default.
• W2040784384 hasConceptScore W2040784384C126322002 @default.
• W2040784384 hasConceptScore W2040784384C169760540 @default.
• W2040784384 hasConceptScore W2040784384C170493617 @default.
• W2040784384 hasConceptScore W2040784384C181199279 @default.
• W2040784384 hasConceptScore W2040784384C185592680 @default.
• W2040784384 hasConceptScore W2040784384C197957613 @default.
• W2040784384 hasConceptScore W2040784384C2775858608 @default.
• W2040784384 hasConceptScore W2040784384C2776834122 @default.
• W2040784384 hasConceptScore W2040784384C2777421860 @default.
• W2040784384 hasConceptScore W2040784384C2778186239 @default.
• W2040784384 hasConceptScore W2040784384C2779896295 @default.
• W2040784384 hasConceptScore W2040784384C2780837902 @default.
• W2040784384 hasConceptScore W2040784384C2780859938 @default.
• W2040784384 hasConceptScore W2040784384C55493867 @default.
• W2040784384 hasConceptScore W2040784384C61174792 @default.
• W2040784384 hasConceptScore W2040784384C71924100 @default.
• W2040784384 hasConceptScore W2040784384C86803240 @default.
• W2040784384 hasConceptScore W2040784384C9497952 @default.

• next