FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040784461> ?p ?o ?g. }

• W2040784461 abstract "We studied adaptations to acute precipitated opioid withdrawal of spinal μ-opioid receptor (MOR)-coupled regulation of the release of endomorphin 2 (EM2). The release of this highly MOR-selective endogenous opioid from opioid-naive spinal tissue of male rats is subjected to MOR-coupled positive as well as negative modulation via cholera toxin-sensitive G(s) and pertussis toxin-sensitive G(i)/G(o), respectively. The net effect of this concomitant bidirectional modulation is inhibitory. MOR-coupled pleiotropic regulation of EM2 release is retained in opioid-withdrawn spinal tissue of male rats, but the balance of MOR-coupled inhibitory and facilitatory regulation shifted such that facilitatory regulation predominates. Augmented coupling of MOR to G(s) is causally associated with this change. Strikingly, pleiotropic characteristics of MOR-coupled regulation of spinal EM2 release and adaptations thereof to opioid withdrawal are male-specific. In females, MOR-coupled regulation of EM2 release from opioid-naive and -withdrawn spinal tissue does not have a significant G(s)-coupled facilitatory component, and MOR-coupled inhibition of EM2 release persists unabated in withdrawn preparations. The male-specific adaptations to chronic morphine that shift the relative predominance of opposing dual G protein-coupled MOR pathways provides a mechanism for mitigating inhibitory MOR signaling without losing MOR-coupled feedback regulation. These adaptations enable using endogenous EM2 as a substitute for morphine that had been precipitously removed. The sexually dimorphic functionality and regulation of spinal EM2/MOR-coupled signaling suggest the clinical utility of using sex-specific treatments for addiction that harness the activity of endogenous opioids." @default.
• W2040784461 created "2016-06-24" @default.
• W2040784461 creator A5006718766 @default.
• W2040784461 creator A5017055008 @default.
• W2040784461 creator A5081804236 @default.
• W2040784461 creator A5082607533 @default.
• W2040784461 creator A5091124691 @default.
• W2040784461 date "2011-10-04" @default.
• W2040784461 modified "2023-09-26" @default.
• W2040784461 title "Pleiotropic Opioid Regulation of Spinal Endomorphin 2 Release and Its Adaptations to Opioid Withdrawal Are Sexually Dimorphic" @default.
• W2040784461 cites W1497040357 @default.
• W2040784461 cites W1585650753 @default.
• W2040784461 cites W1656098835 @default.
• W2040784461 cites W1776637350 @default.
• W2040784461 cites W1970936844 @default.
• W2040784461 cites W1975262853 @default.
• W2040784461 cites W1983233782 @default.
• W2040784461 cites W2023551439 @default.
• W2040784461 cites W2024424770 @default.
• W2040784461 cites W2025791161 @default.
• W2040784461 cites W2030867449 @default.
• W2040784461 cites W2040401758 @default.
• W2040784461 cites W2040925146 @default.
• W2040784461 cites W2063053298 @default.
• W2040784461 cites W2066162119 @default.
• W2040784461 cites W2069066733 @default.
• W2040784461 cites W2074497285 @default.
• W2040784461 cites W2081456710 @default.
• W2040784461 cites W2083071923 @default.
• W2040784461 cites W2085213284 @default.
• W2040784461 cites W2090882011 @default.
• W2040784461 cites W2091671877 @default.
• W2040784461 cites W2100336692 @default.
• W2040784461 cites W2103868498 @default.
• W2040784461 cites W2114707776 @default.
• W2040784461 cites W2128468891 @default.
• W2040784461 cites W2135431594 @default.
• W2040784461 cites W2144448591 @default.
• W2040784461 cites W4302209129 @default.
• W2040784461 doi "https://doi.org/10.1124/jpet.111.186874" @default.
• W2040784461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3270060" @default.
• W2040784461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21972236" @default.
• W2040784461 hasPublicationYear "2011" @default.
• W2040784461 type Work @default.
• W2040784461 sameAs 2040784461 @default.
• W2040784461 citedByCount "16" @default.
• W2040784461 countsByYear W20407844612012 @default.
• W2040784461 countsByYear W20407844612013 @default.
• W2040784461 countsByYear W20407844612014 @default.
• W2040784461 countsByYear W20407844612015 @default.
• W2040784461 countsByYear W20407844612016 @default.
• W2040784461 countsByYear W20407844612019 @default.
• W2040784461 countsByYear W20407844612021 @default.
• W2040784461 crossrefType "journal-article" @default.
• W2040784461 hasAuthorship W2040784461A5006718766 @default.
• W2040784461 hasAuthorship W2040784461A5017055008 @default.
• W2040784461 hasAuthorship W2040784461A5081804236 @default.
• W2040784461 hasAuthorship W2040784461A5082607533 @default.
• W2040784461 hasAuthorship W2040784461A5091124691 @default.
• W2040784461 hasBestOaLocation W20407844612 @default.
• W2040784461 hasConcept C126322002 @default.
• W2040784461 hasConcept C134018914 @default.
• W2040784461 hasConcept C14397066 @default.
• W2040784461 hasConcept C16613235 @default.
• W2040784461 hasConcept C170493617 @default.
• W2040784461 hasConcept C17077164 @default.
• W2040784461 hasConcept C185592680 @default.
• W2040784461 hasConcept C2779886867 @default.
• W2040784461 hasConcept C2781063702 @default.
• W2040784461 hasConcept C3017995582 @default.
• W2040784461 hasConcept C71924100 @default.
• W2040784461 hasConcept C98274493 @default.
• W2040784461 hasConceptScore W2040784461C126322002 @default.
• W2040784461 hasConceptScore W2040784461C134018914 @default.
• W2040784461 hasConceptScore W2040784461C14397066 @default.
• W2040784461 hasConceptScore W2040784461C16613235 @default.
• W2040784461 hasConceptScore W2040784461C170493617 @default.
• W2040784461 hasConceptScore W2040784461C17077164 @default.
• W2040784461 hasConceptScore W2040784461C185592680 @default.
• W2040784461 hasConceptScore W2040784461C2779886867 @default.
• W2040784461 hasConceptScore W2040784461C2781063702 @default.
• W2040784461 hasConceptScore W2040784461C3017995582 @default.
• W2040784461 hasConceptScore W2040784461C71924100 @default.
• W2040784461 hasConceptScore W2040784461C98274493 @default.
• W2040784461 hasLocation W20407844611 @default.
• W2040784461 hasLocation W20407844612 @default.
• W2040784461 hasLocation W20407844613 @default.
• W2040784461 hasLocation W20407844614 @default.
• W2040784461 hasOpenAccess W2040784461 @default.
• W2040784461 hasPrimaryLocation W20407844611 @default.
• W2040784461 hasRelatedWork W1559763458 @default.
• W2040784461 hasRelatedWork W1965816376 @default.
• W2040784461 hasRelatedWork W1979700346 @default.
• W2040784461 hasRelatedWork W2008349238 @default.
• W2040784461 hasRelatedWork W2017789133 @default.
• W2040784461 hasRelatedWork W2027618182 @default.
• W2040784461 hasRelatedWork W2086139880 @default.
• W2040784461 hasRelatedWork W2106973613 @default.
• W2040784461 hasRelatedWork W2128468891 @default.
• W2040784461 hasRelatedWork W2167896883 @default.

• next