Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040791750> ?p ?o ?g. }
- W2040791750 endingPage "112" @default.
- W2040791750 startingPage "107" @default.
- W2040791750 abstract "Plasminogen isolated from 60 full-term newborns differs from adult plasminogen in carbohydrate composition, kinetic activation constants, and cell binding. Amino acid composition and amino-terminal sequence analysis data indicate that the plasminogens of neonates and adults have the same amino acid sequence. Like the adult, the neonate has two glycoforms, but both have significantly more mannose and sialic acid than the adult forms. The difference in the neonatal glycosylation is probably responsible for the altered migration observed by isoelectric focusing. Moreover, the difference in carbohydrate composition appears to be the basis of the decreased functional activity of the neonatal plasminogen. The kcat/Km ratios indicate that the overall activation rates of the two neonatal plasminogen glycoforms are lower compared with the adult glycoforms. In addition, neonatal plasminogen does not bind as well to cellular receptors compared with adult plasminogen. These studies suggest a basis for the decreased fibrinolytic activity observed in neonates." @default.
- W2040791750 created "2016-06-24" @default.
- W2040791750 creator A5019176945 @default.
- W2040791750 creator A5023169167 @default.
- W2040791750 creator A5078249243 @default.
- W2040791750 creator A5090928660 @default.
- W2040791750 date "1990-07-01" @default.
- W2040791750 modified "2023-10-16" @default.
- W2040791750 title "Neonatal plasminogen displays altered cell surface binding and activation kinetics. Correlation with increased glycosylation of the protein." @default.
- W2040791750 cites W1482596645 @default.
- W2040791750 cites W1494608310 @default.
- W2040791750 cites W1505980680 @default.
- W2040791750 cites W1522140074 @default.
- W2040791750 cites W1523598805 @default.
- W2040791750 cites W1534283098 @default.
- W2040791750 cites W1559877912 @default.
- W2040791750 cites W1563799601 @default.
- W2040791750 cites W1571624606 @default.
- W2040791750 cites W1584663505 @default.
- W2040791750 cites W1762632784 @default.
- W2040791750 cites W1966087742 @default.
- W2040791750 cites W1985016225 @default.
- W2040791750 cites W1987711145 @default.
- W2040791750 cites W1992213833 @default.
- W2040791750 cites W1993729215 @default.
- W2040791750 cites W2012839797 @default.
- W2040791750 cites W2018289835 @default.
- W2040791750 cites W2023409976 @default.
- W2040791750 cites W2024756148 @default.
- W2040791750 cites W2029458605 @default.
- W2040791750 cites W2031119708 @default.
- W2040791750 cites W2033910782 @default.
- W2040791750 cites W2045449689 @default.
- W2040791750 cites W2055202820 @default.
- W2040791750 cites W2073980233 @default.
- W2040791750 cites W2074631079 @default.
- W2040791750 cites W2076056907 @default.
- W2040791750 cites W2081929609 @default.
- W2040791750 cites W2082155638 @default.
- W2040791750 cites W2089234602 @default.
- W2040791750 cites W2094046931 @default.
- W2040791750 cites W2100837269 @default.
- W2040791750 cites W2111412025 @default.
- W2040791750 cites W2121141343 @default.
- W2040791750 cites W2165233066 @default.
- W2040791750 cites W2184999432 @default.
- W2040791750 cites W2344279649 @default.
- W2040791750 cites W2401824567 @default.
- W2040791750 cites W2408508481 @default.
- W2040791750 cites W2414305949 @default.
- W2040791750 cites W2417967356 @default.
- W2040791750 cites W2463614291 @default.
- W2040791750 cites W27915724 @default.
- W2040791750 cites W4206701382 @default.
- W2040791750 doi "https://doi.org/10.1172/jci114671" @default.
- W2040791750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296696" @default.
- W2040791750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2365810" @default.
- W2040791750 hasPublicationYear "1990" @default.
- W2040791750 type Work @default.
- W2040791750 sameAs 2040791750 @default.
- W2040791750 citedByCount "50" @default.
- W2040791750 countsByYear W20407917502012 @default.
- W2040791750 countsByYear W20407917502017 @default.
- W2040791750 countsByYear W20407917502018 @default.
- W2040791750 countsByYear W20407917502019 @default.
- W2040791750 countsByYear W20407917502020 @default.
- W2040791750 countsByYear W20407917502021 @default.
- W2040791750 countsByYear W20407917502023 @default.
- W2040791750 crossrefType "journal-article" @default.
- W2040791750 hasAuthorship W2040791750A5019176945 @default.
- W2040791750 hasAuthorship W2040791750A5023169167 @default.
- W2040791750 hasAuthorship W2040791750A5078249243 @default.
- W2040791750 hasAuthorship W2040791750A5090928660 @default.
- W2040791750 hasBestOaLocation W20407917501 @default.
- W2040791750 hasConcept C104317684 @default.
- W2040791750 hasConcept C126322002 @default.
- W2040791750 hasConcept C134018914 @default.
- W2040791750 hasConcept C167625842 @default.
- W2040791750 hasConcept C170493617 @default.
- W2040791750 hasConcept C181199279 @default.
- W2040791750 hasConcept C185592680 @default.
- W2040791750 hasConcept C2777313579 @default.
- W2040791750 hasConcept C2780115458 @default.
- W2040791750 hasConcept C41183919 @default.
- W2040791750 hasConcept C50476208 @default.
- W2040791750 hasConcept C515207424 @default.
- W2040791750 hasConcept C55493867 @default.
- W2040791750 hasConcept C56856141 @default.
- W2040791750 hasConcept C71924100 @default.
- W2040791750 hasConcept C86803240 @default.
- W2040791750 hasConceptScore W2040791750C104317684 @default.
- W2040791750 hasConceptScore W2040791750C126322002 @default.
- W2040791750 hasConceptScore W2040791750C134018914 @default.
- W2040791750 hasConceptScore W2040791750C167625842 @default.
- W2040791750 hasConceptScore W2040791750C170493617 @default.
- W2040791750 hasConceptScore W2040791750C181199279 @default.
- W2040791750 hasConceptScore W2040791750C185592680 @default.
- W2040791750 hasConceptScore W2040791750C2777313579 @default.