FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040795144> ?p ?o ?g. }

• W2040795144 endingPage "10349" @default.
• W2040795144 startingPage "10345" @default.
• W2040795144 abstract "Molecular chaperones of the Hsp70 class bind unfolded polypeptide chains and are thought to be involved in the cellular folding pathway of many proteins. DnaK, the Hsp70 protein of Escherichia coli, is regulated by the chaperone protein DnaJ and the cofactor GrpE. To gain a biologically relevant understanding of the mechanism of Hsp70 action, we have analyzed a model reaction in which DnaK, DnaJ, and GrpE mediate the folding of denatured firefly luciferase. The binding and release of substrate protein for folding involves the following ATP hydrolysis-dependent cycle: (i) unfolded luciferase binds initially to DnaJ; (ii) upon interaction with luciferase-DnaJ, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable luciferase-DnaK-DnaJ complex; (iii) GrpE releases ADP from DnaK; and (iv) ATP binding to DnaK triggers the release of substrate protein, thus completing the reaction cycle. A single cycle of binding and release leads to folding of only a fraction of luciferase molecules. Several rounds of ATP-dependent interaction with DnaK and DnaJ are required for fully efficient folding." @default.
• W2040795144 created "2016-06-24" @default.
• W2040795144 creator A5011042714 @default.
• W2040795144 creator A5033731135 @default.
• W2040795144 creator A5035080305 @default.
• W2040795144 creator A5039579087 @default.
• W2040795144 creator A5086048712 @default.
• W2040795144 creator A5088323138 @default.
• W2040795144 date "1994-10-25" @default.
• W2040795144 modified "2023-10-16" @default.
• W2040795144 title "The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE." @default.
• W2040795144 cites W1490139598 @default.
• W2040795144 cites W1517396783 @default.
• W2040795144 cites W1532878531 @default.
• W2040795144 cites W1541948779 @default.
• W2040795144 cites W1558079148 @default.
• W2040795144 cites W1575935179 @default.
• W2040795144 cites W1582738866 @default.
• W2040795144 cites W1964652518 @default.
• W2040795144 cites W1965246206 @default.
• W2040795144 cites W1972616722 @default.
• W2040795144 cites W1976004246 @default.
• W2040795144 cites W1977357027 @default.
• W2040795144 cites W1978014671 @default.
• W2040795144 cites W1981188702 @default.
• W2040795144 cites W1983471703 @default.
• W2040795144 cites W2000550127 @default.
• W2040795144 cites W2016735338 @default.
• W2040795144 cites W2021113302 @default.
• W2040795144 cites W2027298000 @default.
• W2040795144 cites W2029467366 @default.
• W2040795144 cites W2032515211 @default.
• W2040795144 cites W2035826838 @default.
• W2040795144 cites W2042511341 @default.
• W2040795144 cites W2042985028 @default.
• W2040795144 cites W2043693325 @default.
• W2040795144 cites W2043825401 @default.
• W2040795144 cites W2051793369 @default.
• W2040795144 cites W2060864422 @default.
• W2040795144 cites W2071044011 @default.
• W2040795144 cites W2072744250 @default.
• W2040795144 cites W2085021338 @default.
• W2040795144 cites W2089457735 @default.
• W2040795144 cites W2128635872 @default.
• W2040795144 cites W2178113031 @default.
• W2040795144 doi "https://doi.org/10.1073/pnas.91.22.10345" @default.
• W2040795144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/45016" @default.
• W2040795144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7937953" @default.
• W2040795144 hasPublicationYear "1994" @default.
• W2040795144 type Work @default.
• W2040795144 sameAs 2040795144 @default.
• W2040795144 citedByCount "476" @default.
• W2040795144 countsByYear W20407951442012 @default.
• W2040795144 countsByYear W20407951442013 @default.
• W2040795144 countsByYear W20407951442014 @default.
• W2040795144 countsByYear W20407951442015 @default.
• W2040795144 countsByYear W20407951442016 @default.
• W2040795144 countsByYear W20407951442017 @default.
• W2040795144 countsByYear W20407951442018 @default.
• W2040795144 countsByYear W20407951442019 @default.
• W2040795144 countsByYear W20407951442020 @default.
• W2040795144 countsByYear W20407951442021 @default.
• W2040795144 countsByYear W20407951442022 @default.
• W2040795144 countsByYear W20407951442023 @default.
• W2040795144 crossrefType "journal-article" @default.
• W2040795144 hasAuthorship W2040795144A5011042714 @default.
• W2040795144 hasAuthorship W2040795144A5033731135 @default.
• W2040795144 hasAuthorship W2040795144A5035080305 @default.
• W2040795144 hasAuthorship W2040795144A5039579087 @default.
• W2040795144 hasAuthorship W2040795144A5086048712 @default.
• W2040795144 hasAuthorship W2040795144A5088323138 @default.
• W2040795144 hasBestOaLocation W20407951442 @default.
• W2040795144 hasConcept C104317684 @default.
• W2040795144 hasConcept C111335760 @default.
• W2040795144 hasConcept C12554922 @default.
• W2040795144 hasConcept C141315368 @default.
• W2040795144 hasConcept C142724271 @default.
• W2040795144 hasConcept C181199279 @default.
• W2040795144 hasConcept C185592680 @default.
• W2040795144 hasConcept C197957613 @default.
• W2040795144 hasConcept C204328495 @default.
• W2040795144 hasConcept C205260736 @default.
• W2040795144 hasConcept C23265538 @default.
• W2040795144 hasConcept C2775962898 @default.
• W2040795144 hasConcept C2779564974 @default.
• W2040795144 hasConcept C54009773 @default.
• W2040795144 hasConcept C547475151 @default.
• W2040795144 hasConcept C55493867 @default.
• W2040795144 hasConcept C68991219 @default.
• W2040795144 hasConcept C71924100 @default.
• W2040795144 hasConcept C86803240 @default.
• W2040795144 hasConcept C87190427 @default.
• W2040795144 hasConcept C98924942 @default.
• W2040795144 hasConceptScore W2040795144C104317684 @default.
• W2040795144 hasConceptScore W2040795144C111335760 @default.
• W2040795144 hasConceptScore W2040795144C12554922 @default.
• W2040795144 hasConceptScore W2040795144C141315368 @default.
• W2040795144 hasConceptScore W2040795144C142724271 @default.

• next