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• W2040796364 abstract "-4-Amino-2-arylbutylbenzamides such as 1 were identified as micromolar MCH 1 receptor (MCH1R) antagonists via screening using a scintillation proximity assay based on [125I]-MCH binding to recombinant, human MCH1R. Subsequent lead optimization efforts using solid-phase parallel synthesis resulted in the defined structure–activity relationships and the identification of 4-amino-2-biarylbutylureas, such as 11g, as potent single digit nanomolar MCH1R antagonists." @default.
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• W2040796364 date "2005-08-01" @default.
• W2040796364 modified "2023-10-08" @default.
• W2040796364 title "Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis" @default.
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• W2040796364 doi "https://doi.org/10.1016/j.bmcl.2005.05.039" @default.
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