Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040798657> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2040798657 endingPage "236" @default.
- W2040798657 startingPage "231" @default.
- W2040798657 abstract "The efficacy of transdermal clonidine, alone and in combination with diuretics, has been demonstrated in several studies involving patients with mild to moderate essential hypertension. In one 3-month open study, 64% of patients (wearing one to three 3.5 cm2 transdermal patches) achieved sustained blood pressure reductions throughout the treatment period. In this large study, side effects requiring discontinuation of drug were not observed. Transdermal clonidine reduced plasma renin activity and urinary aldosterone excretion to the same extent as that reported for oral clonidine. Renal function or serum electrolytes were not affected during therapy with transdermal clonidine. Another study showed that patients receiving oral clonidine and hydrochlorothiazide experienced comparable blood pressure reductions when switched to transdermal patches. Plasma drug concentrations measured during treatment with the transdermal patches were similar to the trough levels observed during treatment with oral clonidine. The equipotency of oral and transdermal therapy in combination with hydrochlorothiazide was also demonstrated in two remaining studies. In one of these studies it was suggested that daily variations in blood pressure induced by the peak and trough drug levels of the oral form were minimized by the stable drug levels characteristics of the transdermal device." @default.
- W2040798657 created "2016-06-24" @default.
- W2040798657 creator A5006801326 @default.
- W2040798657 creator A5042851664 @default.
- W2040798657 date "1984-07-01" @default.
- W2040798657 modified "2023-09-29" @default.
- W2040798657 title "Clinical experience with rate-controlled delivery of antihypertensive therapy by a transdermal system" @default.
- W2040798657 cites W1444636143 @default.
- W2040798657 cites W1977560234 @default.
- W2040798657 cites W1982387835 @default.
- W2040798657 cites W2062659757 @default.
- W2040798657 cites W2063129984 @default.
- W2040798657 cites W2066407009 @default.
- W2040798657 cites W2087821654 @default.
- W2040798657 cites W4246475368 @default.
- W2040798657 cites W4255974390 @default.
- W2040798657 doi "https://doi.org/10.1016/0002-8703(84)90580-5" @default.
- W2040798657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6375331" @default.
- W2040798657 hasPublicationYear "1984" @default.
- W2040798657 type Work @default.
- W2040798657 sameAs 2040798657 @default.
- W2040798657 citedByCount "36" @default.
- W2040798657 countsByYear W20407986572015 @default.
- W2040798657 countsByYear W20407986572020 @default.
- W2040798657 crossrefType "journal-article" @default.
- W2040798657 hasAuthorship W2040798657A5006801326 @default.
- W2040798657 hasAuthorship W2040798657A5042851664 @default.
- W2040798657 hasConcept C126322002 @default.
- W2040798657 hasConcept C126894567 @default.
- W2040798657 hasConcept C138976137 @default.
- W2040798657 hasConcept C198710026 @default.
- W2040798657 hasConcept C205679159 @default.
- W2040798657 hasConcept C2775842315 @default.
- W2040798657 hasConcept C2777056448 @default.
- W2040798657 hasConcept C2778399450 @default.
- W2040798657 hasConcept C2778715236 @default.
- W2040798657 hasConcept C2780361556 @default.
- W2040798657 hasConcept C42219234 @default.
- W2040798657 hasConcept C71924100 @default.
- W2040798657 hasConcept C84393581 @default.
- W2040798657 hasConcept C98274493 @default.
- W2040798657 hasConceptScore W2040798657C126322002 @default.
- W2040798657 hasConceptScore W2040798657C126894567 @default.
- W2040798657 hasConceptScore W2040798657C138976137 @default.
- W2040798657 hasConceptScore W2040798657C198710026 @default.
- W2040798657 hasConceptScore W2040798657C205679159 @default.
- W2040798657 hasConceptScore W2040798657C2775842315 @default.
- W2040798657 hasConceptScore W2040798657C2777056448 @default.
- W2040798657 hasConceptScore W2040798657C2778399450 @default.
- W2040798657 hasConceptScore W2040798657C2778715236 @default.
- W2040798657 hasConceptScore W2040798657C2780361556 @default.
- W2040798657 hasConceptScore W2040798657C42219234 @default.
- W2040798657 hasConceptScore W2040798657C71924100 @default.
- W2040798657 hasConceptScore W2040798657C84393581 @default.
- W2040798657 hasConceptScore W2040798657C98274493 @default.
- W2040798657 hasIssue "1" @default.
- W2040798657 hasLocation W20407986571 @default.
- W2040798657 hasLocation W20407986572 @default.
- W2040798657 hasOpenAccess W2040798657 @default.
- W2040798657 hasPrimaryLocation W20407986571 @default.
- W2040798657 hasRelatedWork W1956080552 @default.
- W2040798657 hasRelatedWork W1966295442 @default.
- W2040798657 hasRelatedWork W1990971120 @default.
- W2040798657 hasRelatedWork W1993593187 @default.
- W2040798657 hasRelatedWork W2040798657 @default.
- W2040798657 hasRelatedWork W2125431201 @default.
- W2040798657 hasRelatedWork W2422052053 @default.
- W2040798657 hasRelatedWork W29882057 @default.
- W2040798657 hasRelatedWork W3094359455 @default.
- W2040798657 hasRelatedWork W4230204649 @default.
- W2040798657 hasVolume "108" @default.
- W2040798657 isParatext "false" @default.
- W2040798657 isRetracted "false" @default.
- W2040798657 magId "2040798657" @default.
- W2040798657 workType "article" @default.