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• W2040801298 abstract "Bone marrow samples from children with acute lymphoblastic leukemia were analyzed for the expression of RUNX1a/b/c isoforms. Obtained patterns were associated with genetic abnormalities and the expression of the RUNX1 regulated gene BLK. RUNX1c was present in all patients, but the expected over-expression of RUNX1a was not observed. Over-expression of total RUNT domain isoforms was detected in patients with extra RUNX1 copies, and unexpectedly, in those with t(4;11). Only expression of the total RUNT domain-containing isoforms and BLK presented positive correlation. Results suggest a more complex role of RUNX1 in leukemogenesis than the proposed antagonism between the isoforms." @default.
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• W2040801298 date "2012-09-01" @default.
• W2040801298 modified "2023-10-18" @default.
• W2040801298 title "Expression of RUNX1 isoforms and its target gene BLK in childhood acute lymphoblastic leukemia" @default.
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• W2040801298 doi "https://doi.org/10.1016/j.leukres.2012.05.019" @default.
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