FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040802012> ?p ?o ?g. }

• W2040802012 endingPage "293" @default.
• W2040802012 startingPage "277" @default.
• W2040802012 abstract "It was Robert Koch who recognized the spectrum of pathology of tuberculosis (TB) in different animal species. The examination of clinical specimens from infected humans and animals confirmed the variable patterns of pathological reactions in different species. Guinea pigs are innately susceptible while humans, mice and rabbits show different level of resistance depending upon their genotype. The studies of TB in laboratory animals such as mice, rabbits and guinea pigs have significantly increased our understanding of the aetiology, virulence and pathogenesis of the disease. The introduction of less than five virulent organisms into guinea pigs by the respiratory route can produce lung lesions, bacteraemia and fatal diseases, which helped the extrapolation of results of such experiments to humans. The similarities in the course of clinical infection between guinea pigs and humans allow us to model different forms of TB and to evaluate the protective efficacy of candidate vaccines in such systems. The only limitation of this model, however, is a dearth of immunological reagents that are required for the qualitative and quantitative evaluation of the immune responses, with special reference to cytokines and cell phenotypes. Another limitation is the higher cost of guinea pigs compared with mice. The rabbit is relatively resistant to Mycobacterium tuberculosis, however following infection with virulent Mycobacterium bovis, the rabbit produces pulmonary cavities like humans. The rabbit model, however, is also limited by the lack of the immunological reagents. Mice are the animal of choice for studying the immunology of mycobacterial infections and have contributed much to our current understanding of the roles of various immunological mechanisms of resistance. The resistance of mice to the development of classic TB disease, however, represents a significant disadvantage of the mouse model. Although non-human primates are closely related to humans, owing to high cost and handing difficulties they have not been exploited to a large extent. As all existing animal models fail to mimic the human disease perfectly, efforts should be focused on the development of the non-human primate(s) as the alternative animal model for TB." @default.
• W2040802012 created "2016-06-24" @default.
• W2040802012 creator A5019627093 @default.
• W2040802012 creator A5072052631 @default.
• W2040802012 date "2005-09-01" @default.
• W2040802012 modified "2023-10-16" @default.
• W2040802012 title "Animal models of tuberculosis" @default.
• W2040802012 cites W1487017627 @default.
• W2040802012 cites W1489330398 @default.
• W2040802012 cites W1493673000 @default.
• W2040802012 cites W1505975876 @default.
• W2040802012 cites W1509377507 @default.
• W2040802012 cites W1514750678 @default.
• W2040802012 cites W1517275946 @default.
• W2040802012 cites W1536595294 @default.
• W2040802012 cites W1538374398 @default.
• W2040802012 cites W1562505691 @default.
• W2040802012 cites W1600671496 @default.
• W2040802012 cites W1600829515 @default.
• W2040802012 cites W1605963129 @default.
• W2040802012 cites W1634196889 @default.
• W2040802012 cites W1671219548 @default.
• W2040802012 cites W1814756613 @default.
• W2040802012 cites W1840174809 @default.
• W2040802012 cites W1854693214 @default.
• W2040802012 cites W1856890084 @default.
• W2040802012 cites W1877277475 @default.
• W2040802012 cites W1886086121 @default.
• W2040802012 cites W1898856107 @default.
• W2040802012 cites W1917802511 @default.
• W2040802012 cites W1920651514 @default.
• W2040802012 cites W1921564254 @default.
• W2040802012 cites W1927067708 @default.
• W2040802012 cites W1930542937 @default.
• W2040802012 cites W1935904707 @default.
• W2040802012 cites W1958512527 @default.
• W2040802012 cites W1961585228 @default.
• W2040802012 cites W1962419639 @default.
• W2040802012 cites W1965911366 @default.
• W2040802012 cites W1969365810 @default.
• W2040802012 cites W1970375004 @default.
• W2040802012 cites W1970801356 @default.
• W2040802012 cites W1978068672 @default.
• W2040802012 cites W1978364383 @default.
• W2040802012 cites W1983996452 @default.
• W2040802012 cites W1989523702 @default.
• W2040802012 cites W1989877475 @default.
• W2040802012 cites W1992452635 @default.
• W2040802012 cites W1995070351 @default.
• W2040802012 cites W1998809543 @default.
• W2040802012 cites W2003969989 @default.
• W2040802012 cites W2006774887 @default.
• W2040802012 cites W2006786435 @default.
• W2040802012 cites W2006824931 @default.
• W2040802012 cites W2008865320 @default.
• W2040802012 cites W2009263783 @default.
• W2040802012 cites W2012304906 @default.
• W2040802012 cites W2017955679 @default.
• W2040802012 cites W2025126145 @default.
• W2040802012 cites W2028497769 @default.
• W2040802012 cites W2028993435 @default.
• W2040802012 cites W2032255587 @default.
• W2040802012 cites W2035827257 @default.
• W2040802012 cites W2036314800 @default.
• W2040802012 cites W2041063967 @default.
• W2040802012 cites W2047374766 @default.
• W2040802012 cites W2048597976 @default.
• W2040802012 cites W2049116741 @default.
• W2040802012 cites W2061734203 @default.
• W2040802012 cites W2065791817 @default.
• W2040802012 cites W2068566509 @default.
• W2040802012 cites W2069496409 @default.
• W2040802012 cites W2072810927 @default.
• W2040802012 cites W2073443008 @default.
• W2040802012 cites W2080097172 @default.
• W2040802012 cites W2080748007 @default.
• W2040802012 cites W2085724079 @default.
• W2040802012 cites W2086578273 @default.
• W2040802012 cites W2087271041 @default.
• W2040802012 cites W2089262366 @default.
• W2040802012 cites W2091105951 @default.
• W2040802012 cites W2092034926 @default.
• W2040802012 cites W2095967285 @default.
• W2040802012 cites W2097168105 @default.
• W2040802012 cites W2103971284 @default.
• W2040802012 cites W2107497821 @default.
• W2040802012 cites W2109484445 @default.
• W2040802012 cites W2110185498 @default.
• W2040802012 cites W2112527321 @default.
• W2040802012 cites W2112944967 @default.
• W2040802012 cites W2114495529 @default.
• W2040802012 cites W2115018365 @default.
• W2040802012 cites W2115802786 @default.
• W2040802012 cites W2117328868 @default.
• W2040802012 cites W2121654558 @default.
• W2040802012 cites W2123181064 @default.
• W2040802012 cites W2123585715 @default.
• W2040802012 cites W2123813752 @default.

• next