FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040802288> ?p ?o ?g. }

• W2040802288 abstract "The role of the chlamydial protease CPAF, previously described as a secreted serine protease processing a wealth of host and chlamydial proteins to promote chlamydial intracellular growth, has recently been questioned by studies from the groups of Tan and Sütterlin, who demonstrated that the reported proteolysis of almost a dozen substrates by CPAF occurred during preparation of cell lysates rather than in intact cells. Valdivia et al. have now compared near-isogenic pairs of CPAF-deficient and secretion-deficient mutants of Chlamydia trachomatis and their wild-type parent. Their report, published in this issue of Pathogens and Disease, is a landmark study in the emerging era of Chlamydia genetics. The results of Tan and Sütterlin are confirmed with a few additions. While CPAF's role in pathogenesis is diminished considerably from these studies, CPAF remains an important factor in chlamydial biology as (1) CPAF mutants produce less infectious yield than wild type; and (2) CPAF is responsible for proteolytic cleavage of vimentin and LAP-1, but only after lysis of the inclusion membrane, not upon CPAF secretion to the cytosol. Here, we briefly review the evidence in support of CPAF's active secretion from the mid-to-late inclusion and conclude that new experimentation to establish whether or not CPAF is actively secreted should precede any new investigation of CPAF's cellular activities during mid-to-late development." @default.
• W2040802288 created "2016-06-24" @default.
• W2040802288 creator A5084152783 @default.
• W2040802288 creator A5091796147 @default.
• W2040802288 date "2014-08-01" @default.
• W2040802288 modified "2023-09-23" @default.
• W2040802288 title "Analysis of CPAF mutants: new functions, new questions (The ins and outs of a chlamydial protease)" @default.
• W2040802288 cites W1497229653 @default.
• W2040802288 cites W1873165610 @default.
• W2040802288 cites W1963495843 @default.
• W2040802288 cites W1966585422 @default.
• W2040802288 cites W1981751768 @default.
• W2040802288 cites W1985860758 @default.
• W2040802288 cites W1993631847 @default.
• W2040802288 cites W2000835085 @default.
• W2040802288 cites W2014811987 @default.
• W2040802288 cites W2018605945 @default.
• W2040802288 cites W2039638264 @default.
• W2040802288 cites W2048608623 @default.
• W2040802288 cites W2048931319 @default.
• W2040802288 cites W2049329481 @default.
• W2040802288 cites W2051589414 @default.
• W2040802288 cites W2057887675 @default.
• W2040802288 cites W2057938527 @default.
• W2040802288 cites W2072522842 @default.
• W2040802288 cites W2073717646 @default.
• W2040802288 cites W2075038734 @default.
• W2040802288 cites W2082345749 @default.
• W2040802288 cites W2084384873 @default.
• W2040802288 cites W2085134477 @default.
• W2040802288 cites W2086787888 @default.
• W2040802288 cites W2087797270 @default.
• W2040802288 cites W2090585432 @default.
• W2040802288 cites W2091634729 @default.
• W2040802288 cites W2093151447 @default.
• W2040802288 cites W2098960679 @default.
• W2040802288 cites W2110068478 @default.
• W2040802288 cites W2111815711 @default.
• W2040802288 cites W2115730809 @default.
• W2040802288 cites W2118084919 @default.
• W2040802288 cites W2118717514 @default.
• W2040802288 cites W2123172767 @default.
• W2040802288 cites W2123848170 @default.
• W2040802288 cites W2127640482 @default.
• W2040802288 cites W2134528522 @default.
• W2040802288 cites W2134917885 @default.
• W2040802288 cites W2134924597 @default.
• W2040802288 cites W2136375714 @default.
• W2040802288 cites W2143608477 @default.
• W2040802288 cites W2146188750 @default.
• W2040802288 cites W2149583819 @default.
• W2040802288 cites W2153833219 @default.
• W2040802288 cites W2166375583 @default.
• W2040802288 doi "https://doi.org/10.1111/2049-632x.12194" @default.
• W2040802288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5914542" @default.
• W2040802288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24942261" @default.
• W2040802288 hasPublicationYear "2014" @default.
• W2040802288 type Work @default.
• W2040802288 sameAs 2040802288 @default.
• W2040802288 citedByCount "14" @default.
• W2040802288 countsByYear W20408022882014 @default.
• W2040802288 countsByYear W20408022882015 @default.
• W2040802288 countsByYear W20408022882016 @default.
• W2040802288 countsByYear W20408022882017 @default.
• W2040802288 countsByYear W20408022882018 @default.
• W2040802288 countsByYear W20408022882019 @default.
• W2040802288 crossrefType "journal-article" @default.
• W2040802288 hasAuthorship W2040802288A5084152783 @default.
• W2040802288 hasAuthorship W2040802288A5091796147 @default.
• W2040802288 hasBestOaLocation W20408022881 @default.
• W2040802288 hasConcept C104317684 @default.
• W2040802288 hasConcept C127716648 @default.
• W2040802288 hasConcept C143065580 @default.
• W2040802288 hasConcept C159047783 @default.
• W2040802288 hasConcept C181199279 @default.
• W2040802288 hasConcept C203750385 @default.
• W2040802288 hasConcept C2776714187 @default.
• W2040802288 hasConcept C2777391075 @default.
• W2040802288 hasConcept C2777807008 @default.
• W2040802288 hasConcept C2780122209 @default.
• W2040802288 hasConcept C2781307694 @default.
• W2040802288 hasConcept C49039625 @default.
• W2040802288 hasConcept C54355233 @default.
• W2040802288 hasConcept C547475151 @default.
• W2040802288 hasConcept C55493867 @default.
• W2040802288 hasConcept C79879829 @default.
• W2040802288 hasConcept C86803240 @default.
• W2040802288 hasConcept C89423630 @default.
• W2040802288 hasConcept C95444343 @default.
• W2040802288 hasConceptScore W2040802288C104317684 @default.
• W2040802288 hasConceptScore W2040802288C127716648 @default.
• W2040802288 hasConceptScore W2040802288C143065580 @default.
• W2040802288 hasConceptScore W2040802288C159047783 @default.
• W2040802288 hasConceptScore W2040802288C181199279 @default.
• W2040802288 hasConceptScore W2040802288C203750385 @default.
• W2040802288 hasConceptScore W2040802288C2776714187 @default.
• W2040802288 hasConceptScore W2040802288C2777391075 @default.
• W2040802288 hasConceptScore W2040802288C2777807008 @default.
• W2040802288 hasConceptScore W2040802288C2780122209 @default.
• W2040802288 hasConceptScore W2040802288C2781307694 @default.

• next