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- W2040802355 endingPage "1072" @default.
- W2040802355 startingPage "1066" @default.
- W2040802355 abstract "Poly(vinyl alcohol) microcapsules have been tailored as carriers to deliver camptothecin, an anticancer drug poorly soluble in water. The capsules have been reacted with a chitosan--folate complex in order to selectively target cancer cells overexpressing the folic acid receptor. Microcapsules decorated with the chitosan--folate complex have been characterized in their uptake and release of camptothecin, following the absorption band at λ = 370 nm diagnostic of the drug molecule. The selectivity of chitosan-folate microcapsules in targeting cancer cells has been demonstrated by fluorescence microscopy using HeLa cells, overexpressing the folate receptor and NIH3t3 fibroblasts as a negative control. The chitosan--folate microcapsules loaded with camptothecin significantly reduce the proliferation of HeLa tumor cells, while they have a negligible effect on fibroblasts. This work demonstrates that the chitosan--folate microcapsules represent a promising system to selectively target hydrophobic drugs, such as camptothecin, to tumor cells." @default.
- W2040802355 created "2016-06-24" @default.
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- W2040802355 date "2011-05-18" @default.
- W2040802355 modified "2023-10-09" @default.
- W2040802355 title "Targeting Tumor Cells through Chitosan-Folate Modified Microcapsules Loaded with Camptothecin" @default.
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- W2040802355 doi "https://doi.org/10.1021/bc100546s" @default.
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