Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040802738> ?p ?o ?g. }
- W2040802738 endingPage "1161" @default.
- W2040802738 startingPage "1149" @default.
- W2040802738 abstract "Abstract Hystidyl‐proline [cyclo(His‐Pro)] is an endogenous cyclic dipeptide produced by the cleavage of thyrotropin releasing hormone. Previous studies have shown that cyclo(His‐Pro) protects against oxidative stress, although the underlying mechanism has remained elusive. Here, we addressed this issue and found that cyclo(His‐Pro) triggered nuclear accumulation of NF‐E2‐related factor‐2 (Nrf2), a transcription factor that up‐regulates antioxidant‐/electrophile‐responsive element (ARE‐EpRE)‐related genes, in PC12 cells. Cyclo(His‐Pro) attenuated reactive oxygen species production, and prevented glutathione depletion caused by glutamate, rotenone, paraquat and β‐amyloid treatment. Moreover, real‐time PCR analyses revealed that cyclo(His‐Pro) induced the expression of a number of ARE‐related genes and protected cells against hydrogen peroxide‐mediated apoptotic death. Furthermore, these effects were abolished by RNA interference‐mediated Nrf2 knockdown. Finally, pharmacological inhibition of p‐38 MAPK partially prevented both cyclo(His‐Pro)‐mediated Nrf2 activation and cellular protection. These results suggest that the signalling mechanism responsible for the cytoprotective actions of cyclo(His‐Pro) would involve p‐38 MAPK activation leading to Nrf2‐mediated up‐regulation of antioxidant cellular defence." @default.
- W2040802738 created "2016-06-24" @default.
- W2040802738 creator A5018775026 @default.
- W2040802738 creator A5023273683 @default.
- W2040802738 creator A5036877260 @default.
- W2040802738 creator A5058571857 @default.
- W2040802738 creator A5063914924 @default.
- W2040802738 creator A5079217444 @default.
- W2040802738 date "2009-06-01" @default.
- W2040802738 modified "2023-10-16" @default.
- W2040802738 title "Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence" @default.
- W2040802738 cites W1485529498 @default.
- W2040802738 cites W1547809857 @default.
- W2040802738 cites W1561096292 @default.
- W2040802738 cites W1584387515 @default.
- W2040802738 cites W1966776682 @default.
- W2040802738 cites W1970014922 @default.
- W2040802738 cites W1974546855 @default.
- W2040802738 cites W1975462466 @default.
- W2040802738 cites W1980941288 @default.
- W2040802738 cites W1988402636 @default.
- W2040802738 cites W1995256270 @default.
- W2040802738 cites W1995946739 @default.
- W2040802738 cites W2001591118 @default.
- W2040802738 cites W2007064404 @default.
- W2040802738 cites W2008344420 @default.
- W2040802738 cites W2016562224 @default.
- W2040802738 cites W2020908803 @default.
- W2040802738 cites W2026440517 @default.
- W2040802738 cites W2033642325 @default.
- W2040802738 cites W2040306513 @default.
- W2040802738 cites W2053350368 @default.
- W2040802738 cites W2055706314 @default.
- W2040802738 cites W2059240823 @default.
- W2040802738 cites W2062834612 @default.
- W2040802738 cites W2065609295 @default.
- W2040802738 cites W2066955062 @default.
- W2040802738 cites W2071905812 @default.
- W2040802738 cites W2073660094 @default.
- W2040802738 cites W2076935230 @default.
- W2040802738 cites W2080435498 @default.
- W2040802738 cites W2093507774 @default.
- W2040802738 cites W2100850228 @default.
- W2040802738 cites W2103650142 @default.
- W2040802738 cites W2125762200 @default.
- W2040802738 cites W2146883699 @default.
- W2040802738 cites W2148454550 @default.
- W2040802738 cites W2159820690 @default.
- W2040802738 doi "https://doi.org/10.1111/j.1582-4934.2008.00326.x" @default.
- W2040802738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4496110" @default.
- W2040802738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18373731" @default.
- W2040802738 hasPublicationYear "2009" @default.
- W2040802738 type Work @default.
- W2040802738 sameAs 2040802738 @default.
- W2040802738 citedByCount "33" @default.
- W2040802738 countsByYear W20408027382012 @default.
- W2040802738 countsByYear W20408027382013 @default.
- W2040802738 countsByYear W20408027382014 @default.
- W2040802738 countsByYear W20408027382015 @default.
- W2040802738 countsByYear W20408027382016 @default.
- W2040802738 countsByYear W20408027382017 @default.
- W2040802738 countsByYear W20408027382018 @default.
- W2040802738 countsByYear W20408027382019 @default.
- W2040802738 countsByYear W20408027382020 @default.
- W2040802738 countsByYear W20408027382021 @default.
- W2040802738 countsByYear W20408027382022 @default.
- W2040802738 countsByYear W20408027382023 @default.
- W2040802738 crossrefType "journal-article" @default.
- W2040802738 hasAuthorship W2040802738A5018775026 @default.
- W2040802738 hasAuthorship W2040802738A5023273683 @default.
- W2040802738 hasAuthorship W2040802738A5036877260 @default.
- W2040802738 hasAuthorship W2040802738A5058571857 @default.
- W2040802738 hasAuthorship W2040802738A5063914924 @default.
- W2040802738 hasAuthorship W2040802738A5079217444 @default.
- W2040802738 hasBestOaLocation W20408027382 @default.
- W2040802738 hasConcept C104317684 @default.
- W2040802738 hasConcept C173396325 @default.
- W2040802738 hasConcept C181199279 @default.
- W2040802738 hasConcept C185592680 @default.
- W2040802738 hasConcept C190283241 @default.
- W2040802738 hasConcept C2776151105 @default.
- W2040802738 hasConcept C2778004101 @default.
- W2040802738 hasConcept C2780967304 @default.
- W2040802738 hasConcept C48349386 @default.
- W2040802738 hasConcept C538909803 @default.
- W2040802738 hasConcept C55493867 @default.
- W2040802738 hasConcept C57074206 @default.
- W2040802738 hasConcept C62478195 @default.
- W2040802738 hasConcept C86339819 @default.
- W2040802738 hasConcept C86803240 @default.
- W2040802738 hasConcept C95444343 @default.
- W2040802738 hasConceptScore W2040802738C104317684 @default.
- W2040802738 hasConceptScore W2040802738C173396325 @default.
- W2040802738 hasConceptScore W2040802738C181199279 @default.
- W2040802738 hasConceptScore W2040802738C185592680 @default.
- W2040802738 hasConceptScore W2040802738C190283241 @default.
- W2040802738 hasConceptScore W2040802738C2776151105 @default.
- W2040802738 hasConceptScore W2040802738C2778004101 @default.