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• W2040802845 abstract "cis-RuII(DMSO)4Cl2 (cis-RDT) reacts in aqueous solution with double-stranded DNA forming RuII- DNA complexes. According to measurements per formed with poly(dGdC) and with poly(dAdT) the most likely sites of reaction in the double-stranded polynucleotides are N-7 of both guanine and adenine. Contrary to what was found with cisplatin (to which cis-RDT is comparable in its oncostatic properties) the reaction with cis-RDT stabilizes the ordered B structure of DNA. However, the reaction produces a marked cleavage of the chain." @default.
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• W2040802845 date "1987-07-01" @default.
• W2040802845 modified "2023-10-18" @default.
• W2040802845 title "Reaction of cis-RuII(DMSO)4Cl2 with DNA and with some of its bases in aqueous solution" @default.
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• W2040802845 doi "https://doi.org/10.1016/s0020-1693(00)87109-1" @default.
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