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- W2040802959 abstract "Stress activates endogenous opioids that modulate nociceptive transmission. Exposure to a potentially infanticidal adult male rat suppresses pain-related behaviors in pre-weaning but not in older rats. This male-induced analgesia is mediated by μ opioid receptors in the periaqueductal gray, a midbrain structure that is innervated by amygdala projections. To determine whether enkephalin, a μ and δ opioid receptor agonist, is activated by male exposure, mRNA levels of its precursor, preproenkephalin, were measured in subdivisions of the amygdala and the periaqueductal gray. In 14-day-old but not in 21-day-old rats, 5 min of male exposure induced analgesia to heat and increased preproenkephalin mRNA levels in the central nucleus of the amygdala but not in the periaqueductal gray. The change in the activation of enkephalinergic neurons in the central amygdala may contribute to the change in stress-induced analgesia during early ontogeny." @default.
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- W2040802959 date "2002-09-01" @default.
- W2040802959 modified "2023-09-28" @default.
- W2040802959 title "Stress-induced preproenkephalin mRNA expression in the amygdala changes during early ontogeny in the rat" @default.
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- W2040802959 doi "https://doi.org/10.1016/s0306-4522(02)00268-3" @default.
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