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- W2040803094 endingPage "160" @default.
- W2040803094 startingPage "145" @default.
- W2040803094 abstract "After 25 years and two unsuccessful Phase III trials, the elusive goal of an effective HIV vaccine receded further when the Phase IIb STEP study was curtailed upon reaching predetermined futility criteria. Analyses to date suggest that the vaccine regimen successfully engendered HIV-specific T-lymphocyte responses. Yet this was at best ineffective, as the group of male subjects with prior immunity to adenovirus-5 appeared to have an increased risk of infection. With the vaccine development pipeline entirely focused on eliciting cell-mediated immunity, and many candidates incorporating recombinant adenoviral vectors, the failure of STEP issues a strong challenge to HIV vaccine scientists on several fronts. Can a vaccine provoking cell-mediated immunity protect against HIV? Does prior immunity to a vaccine vector render it ineffective or even dangerous? And how do we identify the next Phase III vaccine candidate when in vitro immunogenicity and apparent protection in animal models has failed to predict success in humans?" @default.
- W2040803094 created "2016-06-24" @default.
- W2040803094 creator A5031973353 @default.
- W2040803094 creator A5063673979 @default.
- W2040803094 creator A5068421356 @default.
- W2040803094 date "2009-03-01" @default.
- W2040803094 modified "2023-09-27" @default.
- W2040803094 title "Trials and tribulations of HIV vaccines" @default.
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