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• W2040805319 startingPage "821" @default.
• W2040805319 abstract "The pha - 4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R = A/G, K = T/G, Y = T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes." @default.
• W2040805319 created "2016-06-24" @default.
• W2040805319 creator A5083349129 @default.
• W2040805319 creator A5007342674 @default.
• W2040805319 date "2002-02-01" @default.
• W2040805319 modified "2023-09-26" @default.
• W2040805319 title "Regulation of Organogenesis by the <i>Caenorhabditis elegans</i> FoxA Protein PHA-4" @default.
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• W2040805319 doi "https://doi.org/10.1126/science.1065175" @default.
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