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- W2040805913 abstract "Rat liver mltochondria suffer a loss of function during poisoning by carbon tetrachloride (CC14). The nadir of function occurs 40 hrs. after CCI 4 administration (male CFN strain rats, 180-230g., i.i ml CCl4/kg., i.£.), marked by a loss of ATP synthesis coupled to respir~ atlon (respiratory control ratio of 2.0 cf. 5.4 for controls) and an abnormal morphology. Swollen structures, as well as highly cony densed, pleomorphlc forms are seen in mlcrographs of isolated mitochondria instead of the uniform, spherical condensed profile of control mltochondria. Outstanding in mlcrographs of the mitochondrlal fraction is a marked increase in rough microsomes in the preparations from the poisoned animals, Fig. i and Fig. 2. Since restoration of mitochondrlal structure and function is evident after 40 hrs. (Brabec, et al., 1974), preceded by an increased incorporation i_n_n vivo of amino acids into mitochondrial protein (Brabec, et al., 1976), it was considered that the rough microsomal fractions represent part of the cellular mitochondrial repair system. Others have demonstrated that compartmentalization of the rough endoplasmic retlculum occurs, resulting in the translation of specific mRNAs CShoreand Tata, 1977). To determine if the rough microsomal elements contribute to the disruption of mltoohondrlal function, mltochondrlal pellets from chloramphenicol-protected, CCl4-polsoned rats were also examined. Simultaneous administration of CCI 4 and chloramphenlcol (10Qmg/kg~ increase the rat's tolerance of CCI 4 and largely prevent mitockondrial damage (Brabec, et al., 1976). Fig. 3 displays mltochondrla from protected rats poisoned with CCI 4. Rough mlcrosomal contamination ~s evident although these mltochondrla were of high integrity (resplratory control ratio: 4.6) and normal appearance. In vivo amino acid incor, poration into mltochondrlal protein was highest in protected rats, supporting the proposition that the contamination by rough mlcrosomes represents a fragment of endoplasmic reticulum specific for the synthesis of mltochondrlal proteins during restoration following damage induced by CCI 4. This study was supported by PHS grant ES 01024." @default.
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- W2040805913 date "1979-01-01" @default.
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- W2040805913 title "Contamination by rough microsomes of rat liver mitochondria during poisoning by carbon tetrachloride" @default.
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- W2040805913 doi "https://doi.org/10.1016/0047-7206(79)90049-9" @default.
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