Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040807986> ?p ?o ?g. }
- W2040807986 endingPage "346" @default.
- W2040807986 startingPage "338" @default.
- W2040807986 abstract "Enhanced generation of ROS has been reported in models of hypertension such as the spontaneously hypertensive rat (SHR). Impairment of kidney function has been implicated in development and progression of hypertension, and the renal medulla appears to play an important role in regulating long-term blood pressure. A key biomarker of oxidative stress is the formation of protein carbonyls, which we set out to characterize in the SHR medulla. We identified 11 proteins that were differentially carbonylated in SHR medulla in comparison to normotensive wistars including enolase 1, catalase, carbonic anhydrase II, transferrin and members of the aldo–keto-reductase family. This enhanced protein oxidation was not only accompanied by an increase in intracellular iron deposition, but aldo–keto-reductase activity was also significantly less in SHR medulla than in normotensive Wistars. Oxidative stress appears selectively to target a subset of proteins in SHR kidney and modification of these proteins may in turn contribute to the renopathy associated with hypertension." @default.
- W2040807986 created "2016-06-24" @default.
- W2040807986 creator A5000680867 @default.
- W2040807986 creator A5003366258 @default.
- W2040807986 creator A5010778183 @default.
- W2040807986 creator A5086139767 @default.
- W2040807986 date "2009-03-01" @default.
- W2040807986 modified "2023-09-27" @default.
- W2040807986 title "Protein carbonylation in kidney medulla of the spontaneously hypertensive rat" @default.
- W2040807986 cites W1502736133 @default.
- W2040807986 cites W1581414347 @default.
- W2040807986 cites W1601924230 @default.
- W2040807986 cites W1770562442 @default.
- W2040807986 cites W1838484704 @default.
- W2040807986 cites W1972310474 @default.
- W2040807986 cites W1975781920 @default.
- W2040807986 cites W1977075298 @default.
- W2040807986 cites W1978350721 @default.
- W2040807986 cites W1981951415 @default.
- W2040807986 cites W1982318505 @default.
- W2040807986 cites W1982628508 @default.
- W2040807986 cites W1986677840 @default.
- W2040807986 cites W1987920125 @default.
- W2040807986 cites W1994599750 @default.
- W2040807986 cites W1996499484 @default.
- W2040807986 cites W1996931010 @default.
- W2040807986 cites W1999197280 @default.
- W2040807986 cites W2001426234 @default.
- W2040807986 cites W2003975298 @default.
- W2040807986 cites W2004301150 @default.
- W2040807986 cites W2009451984 @default.
- W2040807986 cites W2010302435 @default.
- W2040807986 cites W2011451357 @default.
- W2040807986 cites W2015737677 @default.
- W2040807986 cites W2018323250 @default.
- W2040807986 cites W2019245230 @default.
- W2040807986 cites W2023419047 @default.
- W2040807986 cites W2025068702 @default.
- W2040807986 cites W2033546952 @default.
- W2040807986 cites W2035816996 @default.
- W2040807986 cites W2041646709 @default.
- W2040807986 cites W2044138368 @default.
- W2040807986 cites W2060069451 @default.
- W2040807986 cites W2063858579 @default.
- W2040807986 cites W2064063201 @default.
- W2040807986 cites W2077846605 @default.
- W2040807986 cites W2085847434 @default.
- W2040807986 cites W2087105950 @default.
- W2040807986 cites W2089611683 @default.
- W2040807986 cites W2096031729 @default.
- W2040807986 cites W2097446827 @default.
- W2040807986 cites W2098291803 @default.
- W2040807986 cites W2098684354 @default.
- W2040807986 cites W2118287470 @default.
- W2040807986 cites W2122886157 @default.
- W2040807986 cites W2124154927 @default.
- W2040807986 cites W2128892956 @default.
- W2040807986 cites W2133312408 @default.
- W2040807986 cites W2137737171 @default.
- W2040807986 cites W2139979544 @default.
- W2040807986 cites W2140704005 @default.
- W2040807986 cites W2146033970 @default.
- W2040807986 cites W2149677526 @default.
- W2040807986 cites W2151966439 @default.
- W2040807986 cites W2154207789 @default.
- W2040807986 cites W2162542232 @default.
- W2040807986 cites W2163357587 @default.
- W2040807986 cites W2225273165 @default.
- W2040807986 cites W4242910783 @default.
- W2040807986 cites W4247794967 @default.
- W2040807986 cites W4253408758 @default.
- W2040807986 doi "https://doi.org/10.1002/prca.200780098" @default.
- W2040807986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26238751" @default.
- W2040807986 hasPublicationYear "2009" @default.
- W2040807986 type Work @default.
- W2040807986 sameAs 2040807986 @default.
- W2040807986 citedByCount "20" @default.
- W2040807986 countsByYear W20408079862012 @default.
- W2040807986 countsByYear W20408079862013 @default.
- W2040807986 countsByYear W20408079862014 @default.
- W2040807986 countsByYear W20408079862015 @default.
- W2040807986 countsByYear W20408079862016 @default.
- W2040807986 countsByYear W20408079862018 @default.
- W2040807986 countsByYear W20408079862020 @default.
- W2040807986 countsByYear W20408079862022 @default.
- W2040807986 countsByYear W20408079862023 @default.
- W2040807986 crossrefType "journal-article" @default.
- W2040807986 hasAuthorship W2040807986A5000680867 @default.
- W2040807986 hasAuthorship W2040807986A5003366258 @default.
- W2040807986 hasAuthorship W2040807986A5010778183 @default.
- W2040807986 hasAuthorship W2040807986A5086139767 @default.
- W2040807986 hasConcept C126322002 @default.
- W2040807986 hasConcept C134018914 @default.
- W2040807986 hasConcept C17291353 @default.
- W2040807986 hasConcept C185592680 @default.
- W2040807986 hasConcept C2776151105 @default.
- W2040807986 hasConcept C2778979269 @default.
- W2040807986 hasConcept C2780091579 @default.