FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040809050> ?p ?o ?g. }

• W2040809050 endingPage "1615" @default.
• W2040809050 startingPage "1607" @default.
• W2040809050 abstract "Activity of carnosinase (CN1), the only dipeptidase with substrate specificity for carnosine or homocarnosine, varies greatly between individuals but increases clearly and significantly with age. Surprisingly, the lower CN1 activity in children is not reflected by differences in CN1 protein concentrations. CN1 is present in different allosteric conformations in children and adults since all sera obtained from children but not from adults were positive in ELISA and addition of DTT to the latter sera increased OD450 values. There was no quantitative difference in the amount of monomeric CN1 between children and adults. Further, CN1 activity was dose dependently inhibited by homocarnosine. Addition of 80 microM homocarnosine lowered V (max) for carnosine from 440 to 356 pmol/min/microg and increased K (m) from 175 to 210 microM. The estimated K (i) for homocarnosine was higher (240 microM). Homocarnosine inhibits carnosine degradation and high homocarnosine concentrations in cerebrospinal fluid (CSF) may explain the lower carnosine degradation in CSF compared to serum. Because CN1 is implicated in the susceptibility for diabetic nephropathy (DN), our findings may have clinical implications for the treatment of diabetic patients with a high risk to develop DN. Homocarnosine treatment can be expected to reduce CN1 activity toward carnosine, resulting in higher carnosine levels." @default.
• W2040809050 created "2016-06-24" @default.
• W2040809050 creator A5001782922 @default.
• W2040809050 creator A5012889786 @default.
• W2040809050 creator A5016428893 @default.
• W2040809050 creator A5018799656 @default.
• W2040809050 creator A5030948132 @default.
• W2040809050 creator A5043614478 @default.
• W2040809050 creator A5046453197 @default.
• W2040809050 creator A5048064970 @default.
• W2040809050 creator A5049242773 @default.
• W2040809050 creator A5056926938 @default.
• W2040809050 creator A5067775422 @default.
• W2040809050 creator A5071563037 @default.
• W2040809050 creator A5072267405 @default.
• W2040809050 creator A5090027115 @default.
• W2040809050 date "2009-11-14" @default.
• W2040809050 modified "2023-10-14" @default.
• W2040809050 title "Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity" @default.
• W2040809050 cites W1714314790 @default.
• W2040809050 cites W1904840095 @default.
• W2040809050 cites W1971860549 @default.
• W2040809050 cites W1991477312 @default.
• W2040809050 cites W2002315912 @default.
• W2040809050 cites W2009421118 @default.
• W2040809050 cites W2018072158 @default.
• W2040809050 cites W2022076154 @default.
• W2040809050 cites W2028770038 @default.
• W2040809050 cites W2030719457 @default.
• W2040809050 cites W2031932093 @default.
• W2040809050 cites W2033391106 @default.
• W2040809050 cites W2033930161 @default.
• W2040809050 cites W2048587657 @default.
• W2040809050 cites W2058580121 @default.
• W2040809050 cites W2062285406 @default.
• W2040809050 cites W2062347446 @default.
• W2040809050 cites W2067320274 @default.
• W2040809050 cites W2067758151 @default.
• W2040809050 cites W2070825060 @default.
• W2040809050 cites W2073342777 @default.
• W2040809050 cites W2074434246 @default.
• W2040809050 cites W2088917076 @default.
• W2040809050 cites W2093330722 @default.
• W2040809050 cites W2130957616 @default.
• W2040809050 cites W2131250080 @default.
• W2040809050 cites W2131274976 @default.
• W2040809050 cites W2132550409 @default.
• W2040809050 cites W2133414832 @default.
• W2040809050 cites W2140797812 @default.
• W2040809050 cites W2313944243 @default.
• W2040809050 cites W2400490389 @default.
• W2040809050 doi "https://doi.org/10.1007/s00726-009-0367-z" @default.
• W2040809050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19915793" @default.
• W2040809050 hasPublicationYear "2009" @default.
• W2040809050 type Work @default.
• W2040809050 sameAs 2040809050 @default.
• W2040809050 citedByCount "37" @default.
• W2040809050 countsByYear W20408090502012 @default.
• W2040809050 countsByYear W20408090502013 @default.
• W2040809050 countsByYear W20408090502014 @default.
• W2040809050 countsByYear W20408090502015 @default.
• W2040809050 countsByYear W20408090502016 @default.
• W2040809050 countsByYear W20408090502017 @default.
• W2040809050 countsByYear W20408090502018 @default.
• W2040809050 countsByYear W20408090502019 @default.
• W2040809050 countsByYear W20408090502020 @default.
• W2040809050 countsByYear W20408090502021 @default.
• W2040809050 countsByYear W20408090502022 @default.
• W2040809050 countsByYear W20408090502023 @default.
• W2040809050 crossrefType "journal-article" @default.
• W2040809050 hasAuthorship W2040809050A5001782922 @default.
• W2040809050 hasAuthorship W2040809050A5012889786 @default.
• W2040809050 hasAuthorship W2040809050A5016428893 @default.
• W2040809050 hasAuthorship W2040809050A5018799656 @default.
• W2040809050 hasAuthorship W2040809050A5030948132 @default.
• W2040809050 hasAuthorship W2040809050A5043614478 @default.
• W2040809050 hasAuthorship W2040809050A5046453197 @default.
• W2040809050 hasAuthorship W2040809050A5048064970 @default.
• W2040809050 hasAuthorship W2040809050A5049242773 @default.
• W2040809050 hasAuthorship W2040809050A5056926938 @default.
• W2040809050 hasAuthorship W2040809050A5067775422 @default.
• W2040809050 hasAuthorship W2040809050A5071563037 @default.
• W2040809050 hasAuthorship W2040809050A5072267405 @default.
• W2040809050 hasAuthorship W2040809050A5090027115 @default.
• W2040809050 hasBestOaLocation W20408090502 @default.
• W2040809050 hasConcept C126322002 @default.
• W2040809050 hasConcept C134018914 @default.
• W2040809050 hasConcept C166342909 @default.
• W2040809050 hasConcept C181199279 @default.
• W2040809050 hasConcept C185592680 @default.
• W2040809050 hasConcept C18903297 @default.
• W2040809050 hasConcept C2777289219 @default.
• W2040809050 hasConcept C2780687331 @default.
• W2040809050 hasConcept C55493867 @default.
• W2040809050 hasConcept C71924100 @default.
• W2040809050 hasConcept C86803240 @default.
• W2040809050 hasConceptScore W2040809050C126322002 @default.
• W2040809050 hasConceptScore W2040809050C134018914 @default.

• next