FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040822031> ?p ?o ?g. }

• W2040822031 endingPage "202" @default.
• W2040822031 startingPage "198" @default.
• W2040822031 abstract "1 The effects of betaxolol, (±)-l-[4-[2-(cyclopropylmethoxy) ethyl] phenoxy]-3-(isopropylamino)-2-propanol hydrochloride, a β1-selective adrenoceptor antagonist, on voltage-dependent Ca2+ channels were investigated in single smooth muscle cells from guinea-pig mesenteric artery and portal vein using a whole-cell variant of the patch-clamp technique. Ca2+ channel currents were recorded with bath solutions contained 10 mM Ba2+ for arterial cells and 2mMCa2+ for venous cells. 2 Betaxolol inhibited Ca2+ channel currents dose-dependently in both mesenteric artery cells and portal vein cells. The two isomers, (+)-betaxolol and (−)−betaxolol (relative β-antagonistic efficacies of 0.1 and 1, respectively), had similar potencies for inhibiting Ca2+ channel currents in portal vein cells. Propranolol did not inhibit the currents. Thus the inhibitory action of betaxolol on Ca2+ channel currents was independent of the β-adrenoceptor. 3 The inhibitory action of betaxolol on Ca2+ channel currents was compared with that of diltiazem and of nifedipine in mesenteric artery cells. The current inhibition depended on the stimulation frequency with all drugs (use-dependent block). All drugs also accelerated the current decay and shifted the voltage-dependent inactivation curve in a negative direction. 4 In conclusion, betaxolol inhibited Ca2+ channel currents in vascular smooth muscle cells. The mode of inhibitory action was similar to that of diltiazem and nifedipine. Our results suggest that betaxolol is a unique β-adrenoceptor antagonist that has a direct inhibitory action on voltage-dependent Ca2+ channels in vascular smooth muscle cells." @default.
• W2040822031 created "2016-06-24" @default.
• W2040822031 creator A5001022255 @default.
• W2040822031 creator A5011399496 @default.
• W2040822031 creator A5016435730 @default.
• W2040822031 creator A5027751730 @default.
• W2040822031 date "1995-05-01" @default.
• W2040822031 modified "2023-09-30" @default.
• W2040822031 title "Inhibitory action of betaxolol, a β-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea-pig artery and vein" @default.
• W2040822031 cites W1992250560 @default.
• W2040822031 cites W1997511216 @default.
• W2040822031 cites W1998236781 @default.
• W2040822031 cites W2009667219 @default.
• W2040822031 cites W2015426350 @default.
• W2040822031 cites W2018931883 @default.
• W2040822031 cites W2044462613 @default.
• W2040822031 cites W2045141860 @default.
• W2040822031 cites W2051117692 @default.
• W2040822031 cites W2052044716 @default.
• W2040822031 cites W2077124699 @default.
• W2040822031 cites W2077936658 @default.
• W2040822031 cites W2080962219 @default.
• W2040822031 cites W2090140333 @default.
• W2040822031 cites W2147109331 @default.
• W2040822031 cites W2164303608 @default.
• W2040822031 cites W4250082046 @default.
• W2040822031 doi "https://doi.org/10.1111/j.1476-5381.1995.tb16339.x" @default.
• W2040822031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1908754" @default.
• W2040822031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7647977" @default.
• W2040822031 hasPublicationYear "1995" @default.
• W2040822031 type Work @default.
• W2040822031 sameAs 2040822031 @default.
• W2040822031 citedByCount "46" @default.
• W2040822031 countsByYear W20408220312013 @default.
• W2040822031 countsByYear W20408220312014 @default.
• W2040822031 countsByYear W20408220312015 @default.
• W2040822031 countsByYear W20408220312016 @default.
• W2040822031 countsByYear W20408220312023 @default.
• W2040822031 crossrefType "journal-article" @default.
• W2040822031 hasAuthorship W2040822031A5001022255 @default.
• W2040822031 hasAuthorship W2040822031A5011399496 @default.
• W2040822031 hasAuthorship W2040822031A5016435730 @default.
• W2040822031 hasAuthorship W2040822031A5027751730 @default.
• W2040822031 hasBestOaLocation W20408220312 @default.
• W2040822031 hasConcept C126322002 @default.
• W2040822031 hasConcept C134018914 @default.
• W2040822031 hasConcept C147944092 @default.
• W2040822031 hasConcept C169760540 @default.
• W2040822031 hasConcept C170493617 @default.
• W2040822031 hasConcept C17077164 @default.
• W2040822031 hasConcept C185263204 @default.
• W2040822031 hasConcept C185592680 @default.
• W2040822031 hasConcept C2776741139 @default.
• W2040822031 hasConcept C2776885963 @default.
• W2040822031 hasConcept C2778073030 @default.
• W2040822031 hasConcept C2778527774 @default.
• W2040822031 hasConcept C2779066535 @default.
• W2040822031 hasConcept C2779395532 @default.
• W2040822031 hasConcept C2779938033 @default.
• W2040822031 hasConcept C2780648677 @default.
• W2040822031 hasConcept C2781046184 @default.
• W2040822031 hasConcept C2992686903 @default.
• W2040822031 hasConcept C519063684 @default.
• W2040822031 hasConcept C71924100 @default.
• W2040822031 hasConcept C85520022 @default.
• W2040822031 hasConcept C86803240 @default.
• W2040822031 hasConcept C98274493 @default.
• W2040822031 hasConceptScore W2040822031C126322002 @default.
• W2040822031 hasConceptScore W2040822031C134018914 @default.
• W2040822031 hasConceptScore W2040822031C147944092 @default.
• W2040822031 hasConceptScore W2040822031C169760540 @default.
• W2040822031 hasConceptScore W2040822031C170493617 @default.
• W2040822031 hasConceptScore W2040822031C17077164 @default.
• W2040822031 hasConceptScore W2040822031C185263204 @default.
• W2040822031 hasConceptScore W2040822031C185592680 @default.
• W2040822031 hasConceptScore W2040822031C2776741139 @default.
• W2040822031 hasConceptScore W2040822031C2776885963 @default.
• W2040822031 hasConceptScore W2040822031C2778073030 @default.
• W2040822031 hasConceptScore W2040822031C2778527774 @default.
• W2040822031 hasConceptScore W2040822031C2779066535 @default.
• W2040822031 hasConceptScore W2040822031C2779395532 @default.
• W2040822031 hasConceptScore W2040822031C2779938033 @default.
• W2040822031 hasConceptScore W2040822031C2780648677 @default.
• W2040822031 hasConceptScore W2040822031C2781046184 @default.
• W2040822031 hasConceptScore W2040822031C2992686903 @default.
• W2040822031 hasConceptScore W2040822031C519063684 @default.
• W2040822031 hasConceptScore W2040822031C71924100 @default.
• W2040822031 hasConceptScore W2040822031C85520022 @default.
• W2040822031 hasConceptScore W2040822031C86803240 @default.
• W2040822031 hasConceptScore W2040822031C98274493 @default.
• W2040822031 hasIssue "1" @default.
• W2040822031 hasLocation W20408220311 @default.
• W2040822031 hasLocation W20408220312 @default.
• W2040822031 hasLocation W20408220313 @default.
• W2040822031 hasLocation W20408220314 @default.
• W2040822031 hasOpenAccess W2040822031 @default.
• W2040822031 hasPrimaryLocation W20408220311 @default.
• W2040822031 hasRelatedWork W2006443142 @default.

• next