Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040826030> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2040826030 endingPage "11" @default.
- W2040826030 startingPage "6" @default.
- W2040826030 abstract "We recently isolated a novel cDNA, designated ELKS, that was fused to RET cDNA in a papillary thyroid carcinoma. Its encoded polypeptide sequence was rich in glutamic acid (E), leucine (L), lysine (K), and serine (S), and was characterized by the presence of nine alpha-helical coiled-coil domains consisting of periodic heptad repeats. We have now cloned the entire structure of the human ELKS gene from within a 700-kb genomic region represented by overlapping bacteriophage P1-derived artificial chromosome (PAC) and bacterial artificial chromosome (BAC) clones, and localized it to chromosomal band 12p13.3 by fluorescence in situ hybridization. The gene is approximately 500 kb long, with 19 exons and 18 introns; the transcription initiation site within exon 1 is separate from the initiation codon (in exon 2). Analysis of the exon/intron structure revealed that introns interrupt the coding sequence in such a way that many functional segments of the protein are encoded by distinct exons. Exon 1 encodes the 5' non-coding region; exons 2, 3, 6, 7, 8, 9, 11, 14, and 15 encode the nine coiled-coil domains. Exons 17-19 constitute the 3' non-coding region. Analysis of the region immediately upstream of exon 1 showed that it was extremely rich in G/C nucleotides and contained multiple Sp-1 and AP2 binding sequences. The ELKS-RET gene fusion rearrangement we had observed in a papillary thyroid carcinoma occurred between intron 10 of the ELKS gene and intron 11 of RET." @default.
- W2040826030 created "2016-06-24" @default.
- W2040826030 creator A5010432361 @default.
- W2040826030 creator A5015752932 @default.
- W2040826030 creator A5054621091 @default.
- W2040826030 creator A5083544126 @default.
- W2040826030 creator A5088941541 @default.
- W2040826030 date "2000-01-01" @default.
- W2040826030 modified "2023-10-15" @default.
- W2040826030 title "Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma" @default.
- W2040826030 cites W1624438326 @default.
- W2040826030 cites W1965051773 @default.
- W2040826030 cites W1982745900 @default.
- W2040826030 cites W2028093783 @default.
- W2040826030 cites W2085745426 @default.
- W2040826030 cites W2087156384 @default.
- W2040826030 cites W2091309613 @default.
- W2040826030 cites W2116764753 @default.
- W2040826030 cites W2128176727 @default.
- W2040826030 cites W2153406820 @default.
- W2040826030 cites W2413478565 @default.
- W2040826030 doi "https://doi.org/10.1007/s100380050002" @default.
- W2040826030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10697956" @default.
- W2040826030 hasPublicationYear "2000" @default.
- W2040826030 type Work @default.
- W2040826030 sameAs 2040826030 @default.
- W2040826030 citedByCount "11" @default.
- W2040826030 countsByYear W20408260302016 @default.
- W2040826030 countsByYear W20408260302019 @default.
- W2040826030 crossrefType "journal-article" @default.
- W2040826030 hasAuthorship W2040826030A5010432361 @default.
- W2040826030 hasAuthorship W2040826030A5015752932 @default.
- W2040826030 hasAuthorship W2040826030A5054621091 @default.
- W2040826030 hasAuthorship W2040826030A5083544126 @default.
- W2040826030 hasAuthorship W2040826030A5088941541 @default.
- W2040826030 hasBestOaLocation W20408260301 @default.
- W2040826030 hasConcept C104317684 @default.
- W2040826030 hasConcept C153911025 @default.
- W2040826030 hasConcept C156446351 @default.
- W2040826030 hasConcept C36823959 @default.
- W2040826030 hasConcept C54355233 @default.
- W2040826030 hasConcept C86803240 @default.
- W2040826030 hasConcept C91779695 @default.
- W2040826030 hasConcept C94671646 @default.
- W2040826030 hasConceptScore W2040826030C104317684 @default.
- W2040826030 hasConceptScore W2040826030C153911025 @default.
- W2040826030 hasConceptScore W2040826030C156446351 @default.
- W2040826030 hasConceptScore W2040826030C36823959 @default.
- W2040826030 hasConceptScore W2040826030C54355233 @default.
- W2040826030 hasConceptScore W2040826030C86803240 @default.
- W2040826030 hasConceptScore W2040826030C91779695 @default.
- W2040826030 hasConceptScore W2040826030C94671646 @default.
- W2040826030 hasIssue "1" @default.
- W2040826030 hasLocation W20408260301 @default.
- W2040826030 hasLocation W20408260302 @default.
- W2040826030 hasOpenAccess W2040826030 @default.
- W2040826030 hasPrimaryLocation W20408260301 @default.
- W2040826030 hasRelatedWork W1558988329 @default.
- W2040826030 hasRelatedWork W1999232590 @default.
- W2040826030 hasRelatedWork W2039330132 @default.
- W2040826030 hasRelatedWork W2044022171 @default.
- W2040826030 hasRelatedWork W2049281007 @default.
- W2040826030 hasRelatedWork W2052256823 @default.
- W2040826030 hasRelatedWork W2054014494 @default.
- W2040826030 hasRelatedWork W2085975240 @default.
- W2040826030 hasRelatedWork W2090999728 @default.
- W2040826030 hasRelatedWork W2418488235 @default.
- W2040826030 hasVolume "45" @default.
- W2040826030 isParatext "false" @default.
- W2040826030 isRetracted "false" @default.
- W2040826030 magId "2040826030" @default.
- W2040826030 workType "article" @default.