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• W2040828046 startingPage "91" @default.
• W2040828046 abstract "Melatonin was found to improve pancreatic organ function in diseased animals. To study whether pancreatic bicarbonate secretion is stimulated by melatonin, investigations were done in two human ductal pancreatic adenocarcinoma cell lines MIA PaCa-2 (MIA) and PANC-1 (PANC). Using the fluorescence pH-sensor BCECF-AM, we monitored melatonin effects on basal intracellular pH (pHi), and on pHi recovery after intracellular alkalinization produced by the removal of extracellular HCO3 -/CO2. Exposure to 1µM melatonin for 24hrs and presence of the indoleamine during the experiment increases the basal pHi. Moreover, pHi recovery and HCO3 - secretion are facilitated after the alkaline load. These findings are in line with the observed increase in mRNA expression of the Na+/HCO3 --cotransporter SLC4A4b for the uptake and the Cl-/HCO3 --exchanger SLC26A6 for the secretion of HCO3 -. The reduction in Na+/H+- exchanger SLC9A1 mRNA would favor pHi recovery after alkalinization, but it does not explain the initial increase in pHi. This controversial effect and the requirement for continuous presence of melatonin throughout the experiment suggest that nontranscriptional signalling may contribute to the effects of melatonin on acid/base movements. In summary, we show a stimulatory effect of melatonin on bicarbonate secretion in the pancreatic cancer cell lines which may help to prevent duodenal damage." @default.
• W2040828046 created "2016-06-24" @default.
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• W2040828046 date "2006-01-01" @default.
• W2040828046 modified "2023-10-03" @default.
• W2040828046 title "Melatonin Modulates Acid/Base Transport in Human Pancreatic Carcinoma Cells" @default.
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• W2040828046 doi "https://doi.org/10.1159/000095173" @default.
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