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• W2040830028 endingPage "1217" @default.
• W2040830028 startingPage "1208" @default.
• W2040830028 abstract "The tumor necrosis factor-alpha (TNF-α) influences the ability to limit parasite infection but its over-production might result in inflammatory disorders. The level of Tnf-α gene expression could thus mediate a balance of tolerance/resistance to infections. This study focused on Puumala hantavirus (PUUV) infection in its rodent host, the bank vole (Myodes glareolus). In humans, PUUV is responsible of a mild form of hemorrhagic fever with renal syndrome, nephropathia epidemica (NE). The severity of NE is associated with an over-production of TNF-α. By contrast, PUUV infection in bank vole is chronic and asymptomatic. It is likely that different coevolutionary histories between PUUV and its hosts could lead to different balances of resistance/tolerance to PUUV infection, at least partly mediated by variable production levels of TNF-α. We investigated the hypothesis that bank voles from PUUV endemic areas should exhibit higher levels of tolerance, i.e. lower levels of TNF-α production, than bank voles from areas where PUUV prevalence is low. For this purpose, we analysed variations of Tnf-α gene expression and promoter sequences among European populations of bank voles. Our results revealed an absence of up-regulation of Tnf-α gene expression in PUUV infected bank voles and significant differences in Tnf-α gene expression level with regard to PUUV endemicity. These results corroborated the hypothesis of different balances of tolerance/resistance to PUUV. Two single-nucleotide polymorphism genotypes within the Tnf-α promoter (-302 GG/GG and -296 A/A) were associated with higher Tnf-α gene expression and were more frequent in non-endemic areas. This study emphasized the potential influence of selection acting on TNF-α production and mediating a tolerance/resistance balance to PUUV in bank voles. Further investigations, including the role of phenotypic plasticity and parasite communities on Tnf-α expression levels, should provide important keys to understand the prevalence of PUUV over Europe." @default.
• W2040830028 created "2016-06-24" @default.
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• W2040830028 date "2010-12-01" @default.
• W2040830028 modified "2023-10-17" @default.
• W2040830028 title "Tnf-α expression and promoter sequences reflect the balance of tolerance/resistance to Puumala hantavirus infection in European bank vole populations" @default.
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• W2040830028 cites W1965868683 @default.
• W2040830028 cites W1969662432 @default.
• W2040830028 cites W1970270721 @default.
• W2040830028 cites W1972896014 @default.
• W2040830028 cites W1977927757 @default.
• W2040830028 cites W1980288207 @default.
• W2040830028 cites W1990839249 @default.
• W2040830028 cites W2000746681 @default.
• W2040830028 cites W2007814102 @default.
• W2040830028 cites W2010365240 @default.
• W2040830028 cites W2014958828 @default.
• W2040830028 cites W2015045277 @default.
• W2040830028 cites W2021274912 @default.
• W2040830028 cites W2023450761 @default.
• W2040830028 cites W2031501484 @default.
• W2040830028 cites W2032698789 @default.
• W2040830028 cites W2039976430 @default.
• W2040830028 cites W2040751590 @default.
• W2040830028 cites W2044720356 @default.
• W2040830028 cites W2046457470 @default.
• W2040830028 cites W2051181783 @default.
• W2040830028 cites W2051597633 @default.
• W2040830028 cites W2052119995 @default.
• W2040830028 cites W2053889157 @default.
• W2040830028 cites W2055090334 @default.
• W2040830028 cites W2056325621 @default.
• W2040830028 cites W2057625875 @default.
• W2040830028 cites W2060267424 @default.
• W2040830028 cites W2061542205 @default.
• W2040830028 cites W2063232854 @default.
• W2040830028 cites W2069251911 @default.
• W2040830028 cites W2073409518 @default.
• W2040830028 cites W2073565524 @default.
• W2040830028 cites W2074074707 @default.
• W2040830028 cites W2077054201 @default.
• W2040830028 cites W2077154148 @default.
• W2040830028 cites W2082558006 @default.
• W2040830028 cites W2082684425 @default.
• W2040830028 cites W2088753554 @default.
• W2040830028 cites W2096739243 @default.
• W2040830028 cites W2096868702 @default.
• W2040830028 cites W2098850371 @default.
• W2040830028 cites W2099753659 @default.
• W2040830028 cites W2106882534 @default.
• W2040830028 cites W2108825722 @default.
• W2040830028 cites W2120556433 @default.
• W2040830028 cites W2126342903 @default.
• W2040830028 cites W2129423257 @default.
• W2040830028 cites W2133147430 @default.
• W2040830028 cites W2135577623 @default.
• W2040830028 cites W2137412331 @default.
• W2040830028 cites W2140422292 @default.
• W2040830028 cites W2141689146 @default.
• W2040830028 cites W2142119779 @default.
• W2040830028 cites W2144682968 @default.
• W2040830028 cites W2145666690 @default.
• W2040830028 cites W2146081698 @default.
• W2040830028 cites W2146778847 @default.
• W2040830028 cites W2149250433 @default.
• W2040830028 cites W2151559865 @default.
• W2040830028 cites W2156801313 @default.
• W2040830028 cites W2158738033 @default.
• W2040830028 cites W2161924040 @default.
• W2040830028 cites W2163062455 @default.
• W2040830028 cites W2168438178 @default.
• W2040830028 cites W2176899369 @default.
• W2040830028 cites W2180373448 @default.
• W2040830028 cites W2181079330 @default.
• W2040830028 cites W2253414912 @default.
• W2040830028 cites W2417960111 @default.
• W2040830028 cites W4231311503 @default.
• W2040830028 cites W4245598032 @default.
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• W2040830028 doi "https://doi.org/10.1016/j.meegid.2010.07.022" @default.
• W2040830028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20691810" @default.
• W2040830028 hasPublicationYear "2010" @default.
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