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- W2040832866 abstract "There is an increasing recognition that following traumatic brain injury, a cascade of inflammatory mediators is produced, and contributes to the pathological consequences of central nervous system injury. This review summarises the key literature from pre-clinical models that underlies our understanding of innate inflammation following traumatic brain injury before focussing on the growing evidence from human studies. In addition, the underlying molecular mediators responsible for blood brain barrier dysfunction have been discussed. In particular, we have highlighted the different sampling methodologies available and the difficulties in interpreting human data of this sort. Ultimately, understanding the innate inflammatory response to traumatic brain injury may provide a therapeutic avenue in the treatment of central nervous system disease." @default.
- W2040832866 created "2016-06-24" @default.
- W2040832866 creator A5013479481 @default.
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- W2040832866 creator A5088132218 @default.
- W2040832866 date "2011-11-01" @default.
- W2040832866 modified "2023-10-11" @default.
- W2040832866 title "Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury" @default.
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