FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040834490> ?p ?o ?g. }

• W2040834490 endingPage "1661" @default.
• W2040834490 startingPage "1657" @default.
• W2040834490 abstract "The retinoblastoma (Rb) gene is the prototype for a class of recessive human cancer genes in which loss of activity of both normal alleles is thought to be associated with tumorigenesis. Sixteen of 40 retinoblastomas examined with a complementary DNA probe shown to be the Rb gene had identifiable structural changes of the Rb gene including in some cases homozygous internal deletions with corresponding truncated transcripts. An osteosarcoma also had a homozygous internal deletion with a truncated transcript. In addition, possible hot spots for deletion were identified within the Rb genomic locus. Among those tumors with no identifiable structural changes there was either absence of an Rb transcript or abnormal expression of the Rb transcript. Comparison of the structural changes in the tumor cells and fibroblasts of certain patients provided support for Knudson's two-hit hypothesis for the development of retinoblastoma at the molecular level. The ability to detect germline structural deletions in fibroblasts from some patients with bilateral retinoblastoma also indicates that the isolated gene is useful for diagnostic purposes." @default.
• W2040834490 created "2016-06-24" @default.
• W2040834490 creator A5001547731 @default.
• W2040834490 creator A5012182461 @default.
• W2040834490 creator A5025147400 @default.
• W2040834490 creator A5038406163 @default.
• W2040834490 creator A5059204855 @default.
• W2040834490 creator A5085800731 @default.
• W2040834490 date "1987-06-26" @default.
• W2040834490 modified "2023-10-11" @default.
• W2040834490 title "Structural Evidence for the Authenticity of the Human Retinoblastoma Gene" @default.
• W2040834490 cites W1556555576 @default.
• W2040834490 cites W1970232559 @default.
• W2040834490 cites W1981063871 @default.
• W2040834490 cites W1989976890 @default.
• W2040834490 cites W1992125279 @default.
• W2040834490 cites W1992450235 @default.
• W2040834490 cites W1996465274 @default.
• W2040834490 cites W2006317887 @default.
• W2040834490 cites W2014669590 @default.
• W2040834490 cites W2017060505 @default.
• W2040834490 cites W2021457118 @default.
• W2040834490 cites W2027610342 @default.
• W2040834490 cites W2034440981 @default.
• W2040834490 cites W2037068816 @default.
• W2040834490 cites W2039001926 @default.
• W2040834490 cites W2063998394 @default.
• W2040834490 cites W2064864270 @default.
• W2040834490 cites W2072627259 @default.
• W2040834490 cites W2077858999 @default.
• W2040834490 cites W2093517913 @default.
• W2040834490 cites W2094485880 @default.
• W2040834490 cites W2099742439 @default.
• W2040834490 cites W2110886624 @default.
• W2040834490 doi "https://doi.org/10.1126/science.2885916" @default.
• W2040834490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2885916" @default.
• W2040834490 hasPublicationYear "1987" @default.
• W2040834490 type Work @default.
• W2040834490 sameAs 2040834490 @default.
• W2040834490 citedByCount "770" @default.
• W2040834490 countsByYear W20408344902012 @default.
• W2040834490 countsByYear W20408344902013 @default.
• W2040834490 countsByYear W20408344902014 @default.
• W2040834490 countsByYear W20408344902015 @default.
• W2040834490 countsByYear W20408344902016 @default.
• W2040834490 countsByYear W20408344902017 @default.
• W2040834490 countsByYear W20408344902018 @default.
• W2040834490 countsByYear W20408344902019 @default.
• W2040834490 countsByYear W20408344902020 @default.
• W2040834490 countsByYear W20408344902021 @default.
• W2040834490 countsByYear W20408344902022 @default.
• W2040834490 countsByYear W20408344902023 @default.
• W2040834490 crossrefType "journal-article" @default.
• W2040834490 hasAuthorship W2040834490A5001547731 @default.
• W2040834490 hasAuthorship W2040834490A5012182461 @default.
• W2040834490 hasAuthorship W2040834490A5025147400 @default.
• W2040834490 hasAuthorship W2040834490A5038406163 @default.
• W2040834490 hasAuthorship W2040834490A5059204855 @default.
• W2040834490 hasAuthorship W2040834490A5085800731 @default.
• W2040834490 hasConcept C104317684 @default.
• W2040834490 hasConcept C109825262 @default.
• W2040834490 hasConcept C153911025 @default.
• W2040834490 hasConcept C180754005 @default.
• W2040834490 hasConcept C2776577112 @default.
• W2040834490 hasConcept C502942594 @default.
• W2040834490 hasConcept C54355233 @default.
• W2040834490 hasConcept C555283112 @default.
• W2040834490 hasConcept C84597430 @default.
• W2040834490 hasConcept C86803240 @default.
• W2040834490 hasConceptScore W2040834490C104317684 @default.
• W2040834490 hasConceptScore W2040834490C109825262 @default.
• W2040834490 hasConceptScore W2040834490C153911025 @default.
• W2040834490 hasConceptScore W2040834490C180754005 @default.
• W2040834490 hasConceptScore W2040834490C2776577112 @default.
• W2040834490 hasConceptScore W2040834490C502942594 @default.
• W2040834490 hasConceptScore W2040834490C54355233 @default.
• W2040834490 hasConceptScore W2040834490C555283112 @default.
• W2040834490 hasConceptScore W2040834490C84597430 @default.
• W2040834490 hasConceptScore W2040834490C86803240 @default.
• W2040834490 hasIssue "4809" @default.
• W2040834490 hasLocation W20408344901 @default.
• W2040834490 hasLocation W20408344902 @default.
• W2040834490 hasOpenAccess W2040834490 @default.
• W2040834490 hasPrimaryLocation W20408344901 @default.
• W2040834490 hasRelatedWork W1956762270 @default.
• W2040834490 hasRelatedWork W1989502778 @default.
• W2040834490 hasRelatedWork W2042873259 @default.
• W2040834490 hasRelatedWork W2124478268 @default.
• W2040834490 hasRelatedWork W2125344851 @default.
• W2040834490 hasRelatedWork W2148781080 @default.
• W2040834490 hasRelatedWork W2180824931 @default.
• W2040834490 hasRelatedWork W2361342090 @default.
• W2040834490 hasRelatedWork W2413816897 @default.
• W2040834490 hasRelatedWork W858891458 @default.
• W2040834490 hasVolume "236" @default.
• W2040834490 isParatext "false" @default.
• W2040834490 isRetracted "false" @default.
• W2040834490 magId "2040834490" @default.

• next