Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040839454> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2040839454 endingPage "1995" @default.
- W2040839454 startingPage "1990" @default.
- W2040839454 abstract "There has been controversy as to whether the antiproliferative activity of dietary phenolic substances on cancer cells is due to the bioactivities of phenolics or the generation of hydrogen peroxide (H2O2) in media as an artifact. This study was to investigate whether the formation of H2O2 by different phenolics induces acute toxicity and carcinogenicity in normal rat liver epithelial cells. Gallic acid, one of the major antioxidants present in fruits and vegetables, dose-dependently generated considerably more H2O2 in DMEM media without cells than did quercetin. Gallic acid exerted stronger antiproliferative activity than quercetin on both Caco-2 human colon cancer cells (Caco-2 cells) and WB-F344 normal rat liver epithelial cells (WB cells) cultured in DMEM media, and the effect was partially reduced by catalase. Furthermore, gallic acid (but not quercetin) also inhibited gap-junction intercellular communication (GJIC; a carcinogenic phenomenon), which was in part protected by the addition of catalase. Exogenous H2O2 addition also inhibited the proliferation of both Caco-2 cells and WB cells and inhibited GJIC in a dose-dependent manner, but these effects were almost abolished by the treatment with catalase. From these results it is concluded that the antiproliferative effects of some antioxidants on cancer cells are partially due to their prooxidant actions." @default.
- W2040839454 created "2016-06-24" @default.
- W2040839454 creator A5006050449 @default.
- W2040839454 creator A5009160946 @default.
- W2040839454 creator A5022976734 @default.
- W2040839454 creator A5027913599 @default.
- W2040839454 date "2005-02-19" @default.
- W2040839454 modified "2023-09-26" @default.
- W2040839454 title "Antiproliferative Effects of Dietary Phenolic Substances and Hydrogen Peroxide" @default.
- W2040839454 cites W1983237356 @default.
- W2040839454 cites W2008487276 @default.
- W2040839454 cites W2017486390 @default.
- W2040839454 cites W2017560991 @default.
- W2040839454 cites W2042899863 @default.
- W2040839454 cites W2055128095 @default.
- W2040839454 cites W2065617507 @default.
- W2040839454 cites W2076358165 @default.
- W2040839454 cites W2082414334 @default.
- W2040839454 cites W2084940422 @default.
- W2040839454 cites W2090033836 @default.
- W2040839454 cites W2126762394 @default.
- W2040839454 cites W2142749576 @default.
- W2040839454 cites W2168983663 @default.
- W2040839454 doi "https://doi.org/10.1021/jf0486040" @default.
- W2040839454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15769125" @default.
- W2040839454 hasPublicationYear "2005" @default.
- W2040839454 type Work @default.
- W2040839454 sameAs 2040839454 @default.
- W2040839454 citedByCount "91" @default.
- W2040839454 countsByYear W20408394542012 @default.
- W2040839454 countsByYear W20408394542013 @default.
- W2040839454 countsByYear W20408394542014 @default.
- W2040839454 countsByYear W20408394542015 @default.
- W2040839454 countsByYear W20408394542016 @default.
- W2040839454 countsByYear W20408394542017 @default.
- W2040839454 countsByYear W20408394542018 @default.
- W2040839454 countsByYear W20408394542020 @default.
- W2040839454 countsByYear W20408394542021 @default.
- W2040839454 crossrefType "journal-article" @default.
- W2040839454 hasAuthorship W2040839454A5006050449 @default.
- W2040839454 hasAuthorship W2040839454A5009160946 @default.
- W2040839454 hasAuthorship W2040839454A5022976734 @default.
- W2040839454 hasAuthorship W2040839454A5027913599 @default.
- W2040839454 hasConcept C114246631 @default.
- W2040839454 hasConcept C121608353 @default.
- W2040839454 hasConcept C185592680 @default.
- W2040839454 hasConcept C2778004101 @default.
- W2040839454 hasConcept C2778362808 @default.
- W2040839454 hasConcept C2778979269 @default.
- W2040839454 hasConcept C2781263971 @default.
- W2040839454 hasConcept C533411734 @default.
- W2040839454 hasConcept C54355233 @default.
- W2040839454 hasConcept C55493867 @default.
- W2040839454 hasConcept C79879829 @default.
- W2040839454 hasConcept C86803240 @default.
- W2040839454 hasConcept C96232424 @default.
- W2040839454 hasConcept C98274493 @default.
- W2040839454 hasConceptScore W2040839454C114246631 @default.
- W2040839454 hasConceptScore W2040839454C121608353 @default.
- W2040839454 hasConceptScore W2040839454C185592680 @default.
- W2040839454 hasConceptScore W2040839454C2778004101 @default.
- W2040839454 hasConceptScore W2040839454C2778362808 @default.
- W2040839454 hasConceptScore W2040839454C2778979269 @default.
- W2040839454 hasConceptScore W2040839454C2781263971 @default.
- W2040839454 hasConceptScore W2040839454C533411734 @default.
- W2040839454 hasConceptScore W2040839454C54355233 @default.
- W2040839454 hasConceptScore W2040839454C55493867 @default.
- W2040839454 hasConceptScore W2040839454C79879829 @default.
- W2040839454 hasConceptScore W2040839454C86803240 @default.
- W2040839454 hasConceptScore W2040839454C96232424 @default.
- W2040839454 hasConceptScore W2040839454C98274493 @default.
- W2040839454 hasIssue "6" @default.
- W2040839454 hasLocation W20408394541 @default.
- W2040839454 hasLocation W20408394542 @default.
- W2040839454 hasOpenAccess W2040839454 @default.
- W2040839454 hasPrimaryLocation W20408394541 @default.
- W2040839454 hasRelatedWork W1985452104 @default.
- W2040839454 hasRelatedWork W1991589157 @default.
- W2040839454 hasRelatedWork W2004237207 @default.
- W2040839454 hasRelatedWork W2014112803 @default.
- W2040839454 hasRelatedWork W2094530826 @default.
- W2040839454 hasRelatedWork W2135290125 @default.
- W2040839454 hasRelatedWork W2149176501 @default.
- W2040839454 hasRelatedWork W2395950097 @default.
- W2040839454 hasRelatedWork W2464034055 @default.
- W2040839454 hasRelatedWork W4307127405 @default.
- W2040839454 hasVolume "53" @default.
- W2040839454 isParatext "false" @default.
- W2040839454 isRetracted "false" @default.
- W2040839454 magId "2040839454" @default.
- W2040839454 workType "article" @default.