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- W2040849682 abstract "Colorectal cancer is the third major cause of cancer-related mortality in both men and women worldwide. The beneficial role of n-3 polyunsaturated fatty acids (PUFA) in preventing colon cancer is substantiated by experimental, epidemiological, and clinical data. From a mechanistic perspective, n-3 PUFA are pleiotropic and multifaceted with respect to their molecular mechanisms of action. For example, this class of dietary lipid uniquely modulates membrane and nuclear receptors, sensors/ion channels, and membrane structure/cytoskeletal function, thereby regulating signaling processes that influence patterns of gene expression and cell phenotype. In addition, n-3 PUFA can synergize with other potential chemoprotective agents known to reprogram the chromatin landscape, such as the fermentable fiber product, butyrate. Nutri-epigenomics is an emerging field of research that is focused on the interaction between nutrition and epigenetics. Epigenetics refers to a group of heterogeneous processes that regulate transcription without changing the DNA coding sequence, ranging from DNA methylation, to histone tail modifications and transcription factor activity. One implication of the nutri-epigenome is that it may be possible to reprogram epigenetic marks that are associated with increased disease risk by nutritional or lifestyle interventions. This review will focus on the nutri-epigenomic role of n-3 PUFA, particularly DHA, as well as the combinatorial effects of n-3 PUFA and fermentable fiber in relation to colon cancer." @default.
- W2040849682 created "2016-06-24" @default.
- W2040849682 creator A5019568866 @default.
- W2040849682 creator A5039880005 @default.
- W2040849682 creator A5079800849 @default.
- W2040849682 date "2015-01-27" @default.
- W2040849682 modified "2023-10-16" @default.
- W2040849682 title "Chemoprotective Epigenetic Mechanisms in a Colorectal Cancer Model: Modulation by n-3 PUFA in Combination With Fermentable Fiber" @default.
- W2040849682 cites W1566365189 @default.
- W2040849682 cites W1600103202 @default.
- W2040849682 cites W1637915835 @default.
- W2040849682 cites W1919721665 @default.
- W2040849682 cites W1968028470 @default.
- W2040849682 cites W1968301937 @default.
- W2040849682 cites W1968501452 @default.
- W2040849682 cites W1969811404 @default.
- W2040849682 cites W1972618783 @default.
- W2040849682 cites W1973556786 @default.
- W2040849682 cites W1976214932 @default.
- W2040849682 cites W1982250275 @default.
- W2040849682 cites W1983861014 @default.
- W2040849682 cites W1993472701 @default.
- W2040849682 cites W1996416600 @default.
- W2040849682 cites W1997648536 @default.
- W2040849682 cites W1998717174 @default.
- W2040849682 cites W2000093333 @default.
- W2040849682 cites W2005675676 @default.
- W2040849682 cites W2008090904 @default.
- W2040849682 cites W2008120843 @default.
- W2040849682 cites W2019242560 @default.
- W2040849682 cites W2020210568 @default.
- W2040849682 cites W2021398185 @default.
- W2040849682 cites W2023017849 @default.
- W2040849682 cites W2029524898 @default.
- W2040849682 cites W2030512179 @default.
- W2040849682 cites W2031024962 @default.
- W2040849682 cites W2032025006 @default.
- W2040849682 cites W2033000270 @default.
- W2040849682 cites W2033367659 @default.
- W2040849682 cites W2034269591 @default.
- W2040849682 cites W2034888385 @default.
- W2040849682 cites W2035177367 @default.
- W2040849682 cites W2036411298 @default.
- W2040849682 cites W2036550812 @default.
- W2040849682 cites W2038405737 @default.
- W2040849682 cites W2040895217 @default.
- W2040849682 cites W2049499648 @default.
- W2040849682 cites W2050079849 @default.
- W2040849682 cites W2054215858 @default.
- W2040849682 cites W2054739775 @default.
- W2040849682 cites W2056598586 @default.
- W2040849682 cites W2065833746 @default.
- W2040849682 cites W2066465207 @default.
- W2040849682 cites W2069481796 @default.
- W2040849682 cites W2079273022 @default.
- W2040849682 cites W2082578477 @default.
- W2040849682 cites W2082961519 @default.
- W2040849682 cites W2086811572 @default.
- W2040849682 cites W2089111792 @default.
- W2040849682 cites W2092974774 @default.
- W2040849682 cites W2095762159 @default.
- W2040849682 cites W2097078602 @default.
- W2040849682 cites W2097357124 @default.
- W2040849682 cites W2099062438 @default.
- W2040849682 cites W2102385563 @default.
- W2040849682 cites W2104407508 @default.
- W2040849682 cites W2107221695 @default.
- W2040849682 cites W2109691722 @default.
- W2040849682 cites W2111562236 @default.
- W2040849682 cites W2112213992 @default.
- W2040849682 cites W2112247402 @default.
- W2040849682 cites W2113975924 @default.
- W2040849682 cites W2114995439 @default.
- W2040849682 cites W2115376812 @default.
- W2040849682 cites W2115721874 @default.
- W2040849682 cites W2118783465 @default.
- W2040849682 cites W2118816476 @default.
- W2040849682 cites W2123142851 @default.
- W2040849682 cites W2123182050 @default.
- W2040849682 cites W2123266023 @default.
- W2040849682 cites W2128939035 @default.
- W2040849682 cites W2130907138 @default.
- W2040849682 cites W2132698289 @default.
- W2040849682 cites W2136112988 @default.
- W2040849682 cites W2136759951 @default.
- W2040849682 cites W2137084098 @default.
- W2040849682 cites W2138904934 @default.
- W2040849682 cites W2139318333 @default.
- W2040849682 cites W2141441284 @default.
- W2040849682 cites W2141726287 @default.
- W2040849682 cites W2142133740 @default.
- W2040849682 cites W2143492487 @default.
- W2040849682 cites W2144777242 @default.
- W2040849682 cites W2145864981 @default.
- W2040849682 cites W2146559835 @default.
- W2040849682 cites W2149866700 @default.
- W2040849682 cites W2150277868 @default.
- W2040849682 cites W2151175078 @default.