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• W2040851236 abstract "ABSTRACT We investigated the activity of trimethoprim-sulfamethoxazole (SXT) against Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB). The MIC distribution of SXT was 0.125/2.4 to 2/38 mg/liter for the 100 isolates tested, including multi- and extensively drug-resistant isolates (MDR/XDR-TB), whereas the intracellular MIC 90 of sulfamethoxazole (SMX) for the pansusceptible strain H37Rv was 76 mg/liter. In an exploratory analysis using a ratio of the unbound area under the concentration-time curve from 0 to 24 h over MIC ( f AUC 0–24 /MIC) using ≥25 as a potential target, the cumulative fraction response was ≥90% at doses of ≥2,400 mg of SMX. SXT is a potential treatment option for MDR/XDR-TB." @default.
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• W2040851236 date "2014-12-01" @default.
• W2040851236 modified "2023-10-16" @default.
• W2040851236 title "Intra- and Extracellular Activities of Trimethoprim-Sulfamethoxazole against Susceptible and Multidrug-Resistant Mycobacterium tuberculosis" @default.
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• W2040851236 doi "https://doi.org/10.1128/aac.02995-14" @default.
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