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- W2040851810 endingPage "1181" @default.
- W2040851810 startingPage "1170" @default.
- W2040851810 abstract "The phosphatidylinositol-3 kinase (PI3K) pathway plays a central role in regulating numerous biologic processes, including survival, adhesion, migration, metabolic activity, proliferation, differentiation, and end cell activation through the generation of the potent second messenger PI-3,4,5-trisphosphate (PI-3,4,5-P(3)). To ensure that activation of this pathway is appropriately suppressed/terminated, the ubiquitously expressed 54-kDa tumor suppressor PTEN hydrolyzes PI-3,4,5-P(3) to PI-4,5-P(2), whereas the 145-kDa hematopoietic-restricted SH2-containing inositol 5'-phosphatase SHIP (also known as SHIP1), the 104-kDa stem cell-restricted SHIP sSHIP, and the more widely expressed 150-kDa SHIP2 break it down to PI-3,4-P(2). In this review, we focus on the properties of these phospholipid phosphatases and summarize recent data showing that the activities of these negative regulators often are modulated by simply altering their protein levels. We also highlight the critical role that SHIP plays in lipopolysaccharide-induced macrophage activation and in endotoxin tolerance." @default.
- W2040851810 created "2016-06-24" @default.
- W2040851810 creator A5017180599 @default.
- W2040851810 creator A5022264195 @default.
- W2040851810 creator A5045149595 @default.
- W2040851810 creator A5074839791 @default.
- W2040851810 creator A5079093459 @default.
- W2040851810 date "2003-12-01" @default.
- W2040851810 modified "2023-10-10" @default.
- W2040851810 title "SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide" @default.
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