FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040858742> ?p ?o ?g. }

• W2040858742 endingPage "1287" @default.
• W2040858742 startingPage "1278" @default.
• W2040858742 abstract "The ultradian pulsatile pattern of growth hormone (GH) secretion is markedly sexually dimorphic in rodents as in primates, but the neuroanatomical mechanisms of this phenomenon are not clear. In the arcuate nucleus of the hypothalamus, GH-releasing hormone (GHRH) neurones receive somatostatinergic inputs through the sst2A receptor (sst2A-R) and the percentage of GHRH neurones bearing sst2A-R is higher in female than in male GHRH-enhanced green fluorescent protein (eGFP) mice. In the present study, we hypothesised that sst2A-R expression on GHRH neurones is modulated by gonadal steroids and constitutes a mechanism for sexually differentiated GH secretion. The distribution of sst2A-R on GHRH neurones was evaluated by immunohistochemistry in adult GHRH-eGFP mice gonadectomised and treated for 3 weeks with oestradiol or testosterone implants. In gonadectomised females supplemented with testosterone, sst2A-R distribution on GHRH neurones was reduced to the level seen in intact males, whereas oestradiol implants were ineffective. Conversely, orchidectomy induced a female ‘sst2A phenotype’, which was reversed by testosterone supplementation. Changes in the hepatic expression of GH-dependent genes for major urinary protein-3 and the prolactin receptor reflected the altered steroid influence on GH pulsatile secretion. In the ventromedial-arcuate region, GHRH and sst2-R, as well as GHRH and somatostatin expression as measured by the real-time polymerase chain reaction, were positively correlated in both sexes. By contrast, the positive correlation between ventromedial-arcuate GHRH and periventricular somatostatin expression in males was reversed to a negative one in females. Moreover, the positive correlation between periventricular somatostatin and ventromedial-arcuate sst2-R expressions in males was lost in females. These results suggest that, in the adult mouse, testosterone is a major modulator of sst2A distribution on GHRH neurones. This marked sex difference in sst2A-R distribution may constitute a key element in the genesis of the sexually differentiated pattern of GH secretion, possibly through testosterone-modulated changes in somatostatin inputs from hypophysiotrophic periventricular neurones." @default.
• W2040858742 created "2016-06-24" @default.
• W2040858742 creator A5000209450 @default.
• W2040858742 creator A5043835153 @default.
• W2040858742 creator A5083765071 @default.
• W2040858742 creator A5088510807 @default.
• W2040858742 creator A5089989719 @default.
• W2040858742 date "2008-11-01" @default.
• W2040858742 modified "2023-09-30" @default.
• W2040858742 title "Sexually Dimorphic Distribution of sst2A Receptors on Growth Hormone-Releasing Hormone Neurones in Mice: Modulation by Gonadal Steroids" @default.
• W2040858742 cites W1485730386 @default.
• W2040858742 cites W1568257631 @default.
• W2040858742 cites W1953592402 @default.
• W2040858742 cites W1965023718 @default.
• W2040858742 cites W1965710144 @default.
• W2040858742 cites W1965731452 @default.
• W2040858742 cites W1971807649 @default.
• W2040858742 cites W1975138771 @default.
• W2040858742 cites W1975710657 @default.
• W2040858742 cites W1976276228 @default.
• W2040858742 cites W1976479772 @default.
• W2040858742 cites W1981736657 @default.
• W2040858742 cites W1982021537 @default.
• W2040858742 cites W1985841848 @default.
• W2040858742 cites W1990370031 @default.
• W2040858742 cites W1992149437 @default.
• W2040858742 cites W2002076232 @default.
• W2040858742 cites W2003868618 @default.
• W2040858742 cites W2012314131 @default.
• W2040858742 cites W2017601255 @default.
• W2040858742 cites W2022664083 @default.
• W2040858742 cites W2024995868 @default.
• W2040858742 cites W2033190347 @default.
• W2040858742 cites W2035740905 @default.
• W2040858742 cites W2036239129 @default.
• W2040858742 cites W2043710343 @default.
• W2040858742 cites W2043897447 @default.
• W2040858742 cites W2056439165 @default.
• W2040858742 cites W2061022101 @default.
• W2040858742 cites W2061238958 @default.
• W2040858742 cites W2069668848 @default.
• W2040858742 cites W2075073911 @default.
• W2040858742 cites W2076234617 @default.
• W2040858742 cites W2080963045 @default.
• W2040858742 cites W2089845502 @default.
• W2040858742 cites W2094070922 @default.
• W2040858742 cites W2095098999 @default.
• W2040858742 cites W2100951135 @default.
• W2040858742 cites W2104980041 @default.
• W2040858742 cites W2107277218 @default.
• W2040858742 cites W2108765018 @default.
• W2040858742 cites W2135428072 @default.
• W2040858742 cites W2142402641 @default.
• W2040858742 cites W2153320245 @default.
• W2040858742 cites W2157138442 @default.
• W2040858742 doi "https://doi.org/10.1111/j.1365-2826.2008.01780.x" @default.
• W2040858742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18752655" @default.
• W2040858742 hasPublicationYear "2008" @default.
• W2040858742 type Work @default.
• W2040858742 sameAs 2040858742 @default.
• W2040858742 citedByCount "9" @default.
• W2040858742 countsByYear W20408587422013 @default.
• W2040858742 countsByYear W20408587422016 @default.
• W2040858742 countsByYear W20408587422017 @default.
• W2040858742 countsByYear W20408587422018 @default.
• W2040858742 countsByYear W20408587422022 @default.
• W2040858742 crossrefType "journal-article" @default.
• W2040858742 hasAuthorship W2040858742A5000209450 @default.
• W2040858742 hasAuthorship W2040858742A5043835153 @default.
• W2040858742 hasAuthorship W2040858742A5083765071 @default.
• W2040858742 hasAuthorship W2040858742A5088510807 @default.
• W2040858742 hasAuthorship W2040858742A5089989719 @default.
• W2040858742 hasBestOaLocation W20408587422 @default.
• W2040858742 hasConcept C105083479 @default.
• W2040858742 hasConcept C126322002 @default.
• W2040858742 hasConcept C134018914 @default.
• W2040858742 hasConcept C2776297358 @default.
• W2040858742 hasConcept C2777003273 @default.
• W2040858742 hasConcept C2779064019 @default.
• W2040858742 hasConcept C2779067335 @default.
• W2040858742 hasConcept C2779279991 @default.
• W2040858742 hasConcept C2779938979 @default.
• W2040858742 hasConcept C2780902042 @default.
• W2040858742 hasConcept C71315377 @default.
• W2040858742 hasConcept C71924100 @default.
• W2040858742 hasConcept C86803240 @default.
• W2040858742 hasConceptScore W2040858742C105083479 @default.
• W2040858742 hasConceptScore W2040858742C126322002 @default.
• W2040858742 hasConceptScore W2040858742C134018914 @default.
• W2040858742 hasConceptScore W2040858742C2776297358 @default.
• W2040858742 hasConceptScore W2040858742C2777003273 @default.
• W2040858742 hasConceptScore W2040858742C2779064019 @default.
• W2040858742 hasConceptScore W2040858742C2779067335 @default.
• W2040858742 hasConceptScore W2040858742C2779279991 @default.
• W2040858742 hasConceptScore W2040858742C2779938979 @default.
• W2040858742 hasConceptScore W2040858742C2780902042 @default.
• W2040858742 hasConceptScore W2040858742C71315377 @default.
• W2040858742 hasConceptScore W2040858742C71924100 @default.

• next