FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040861570> ?p ?o ?g. }

• W2040861570 endingPage "e325" @default.
• W2040861570 startingPage "e318" @default.
• W2040861570 abstract "Apolipoprotein A5 (APOA5) gene variants have been shown to be associated with elevated TG levels; the T-1131C (rs662799) variant has been reported to confer risk for the metabolic syndrome in adult populations. Little is known about the APOA5 variants in pediatric population, no such information is available for pediatric obesity at all. Here we examined four haplotype-tagging polymorphisms (T-1131C, IVS3 + G476A [rs2072560], T1259C [rs2266788] and C56G [rs3135506]) and studied also the frequency of major naturally occurring haplotypes of APOA5 in obese children.The polymorphisms were analyzed in 232 obese children, and in 137 healthy, normal weight controls, using PCR-RFLP methods.In the pediatric patients we could confirm the already known adult subjects based association of -1131C, IVS3 + 476A and 1259C variants with elevated triglyceride concentrations, both in obese patients and in the controls. The prevalence of the APOA5*2 haplotype (containing the minor allele of T-1131C, IVS3 + G476A and T1259C SNPs together) was 15.5% in obese children, and 5.80% in the controls (p<0.001); multiple logistic regression analysis revealed that this haplotype confers susceptibility for development of obesity (OR=2.87; 95% CI: 1.29-6.37; p≤0.01). By contrast, the APOA5*4 haplotype (with -1131C alone) did not show similar associations. Our findings also suggest that the APOA5*5 haplotype (1259C alone) can be protective against obesity (OR=0.25; 95% CI: 0.07-0.80; p<0.05).While previous studies in adults demonstrated, that the APOA5 -1131C minor allele confers risk for adult metabolic syndrome, here we show, that the susceptibility nature of this SNP restricted to the APOA5*2 haplotype in pediatric obese subjects." @default.
• W2040861570 created "2016-06-24" @default.
• W2040861570 creator A5003938743 @default.
• W2040861570 creator A5005314660 @default.
• W2040861570 creator A5008784512 @default.
• W2040861570 creator A5017256316 @default.
• W2040861570 creator A5028727773 @default.
• W2040861570 creator A5030968897 @default.
• W2040861570 creator A5040725595 @default.
• W2040861570 creator A5041556601 @default.
• W2040861570 creator A5057342498 @default.
• W2040861570 creator A5063730176 @default.
• W2040861570 creator A5070932071 @default.
• W2040861570 creator A5087262929 @default.
• W2040861570 date "2011-06-01" @default.
• W2040861570 modified "2023-10-17" @default.
• W2040861570 title "Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients" @default.
• W2040861570 cites W1976923914 @default.
• W2040861570 cites W1978386390 @default.
• W2040861570 cites W1995897030 @default.
• W2040861570 cites W1996456709 @default.
• W2040861570 cites W2001677536 @default.
• W2040861570 cites W2007560842 @default.
• W2040861570 cites W2010480529 @default.
• W2040861570 cites W2012414913 @default.
• W2040861570 cites W2015692830 @default.
• W2040861570 cites W2022033175 @default.
• W2040861570 cites W2022996249 @default.
• W2040861570 cites W2023466812 @default.
• W2040861570 cites W2036704981 @default.
• W2040861570 cites W2042657279 @default.
• W2040861570 cites W2049927985 @default.
• W2040861570 cites W2058032165 @default.
• W2040861570 cites W2064493130 @default.
• W2040861570 cites W2070363845 @default.
• W2040861570 cites W2077119666 @default.
• W2040861570 cites W2080916500 @default.
• W2040861570 cites W2087377981 @default.
• W2040861570 cites W2101002597 @default.
• W2040861570 cites W2104129218 @default.
• W2040861570 cites W2113481191 @default.
• W2040861570 cites W2116720735 @default.
• W2040861570 cites W2126545477 @default.
• W2040861570 cites W2127958304 @default.
• W2040861570 cites W2130584210 @default.
• W2040861570 cites W2132287053 @default.
• W2040861570 cites W2133025759 @default.
• W2040861570 cites W2140111840 @default.
• W2040861570 cites W2141000687 @default.
• W2040861570 cites W2144722463 @default.
• W2040861570 cites W2145118099 @default.
• W2040861570 cites W2149160689 @default.
• W2040861570 cites W2162588312 @default.
• W2040861570 cites W2171101992 @default.
• W2040861570 cites W2315613231 @default.
• W2040861570 cites W34900510 @default.
• W2040861570 cites W4210956151 @default.
• W2040861570 cites W4241143726 @default.
• W2040861570 cites W2024379561 @default.
• W2040861570 doi "https://doi.org/10.3109/17477166.2010.490268" @default.
• W2040861570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20883102" @default.
• W2040861570 hasPublicationYear "2011" @default.
• W2040861570 type Work @default.
• W2040861570 sameAs 2040861570 @default.
• W2040861570 citedByCount "20" @default.
• W2040861570 countsByYear W20408615702012 @default.
• W2040861570 countsByYear W20408615702013 @default.
• W2040861570 countsByYear W20408615702014 @default.
• W2040861570 countsByYear W20408615702015 @default.
• W2040861570 countsByYear W20408615702016 @default.
• W2040861570 countsByYear W20408615702017 @default.
• W2040861570 crossrefType "journal-article" @default.
• W2040861570 hasAuthorship W2040861570A5003938743 @default.
• W2040861570 hasAuthorship W2040861570A5005314660 @default.
• W2040861570 hasAuthorship W2040861570A5008784512 @default.
• W2040861570 hasAuthorship W2040861570A5017256316 @default.
• W2040861570 hasAuthorship W2040861570A5028727773 @default.
• W2040861570 hasAuthorship W2040861570A5030968897 @default.
• W2040861570 hasAuthorship W2040861570A5040725595 @default.
• W2040861570 hasAuthorship W2040861570A5041556601 @default.
• W2040861570 hasAuthorship W2040861570A5057342498 @default.
• W2040861570 hasAuthorship W2040861570A5063730176 @default.
• W2040861570 hasAuthorship W2040861570A5070932071 @default.
• W2040861570 hasAuthorship W2040861570A5087262929 @default.
• W2040861570 hasConcept C104317684 @default.
• W2040861570 hasConcept C126322002 @default.
• W2040861570 hasConcept C134018914 @default.
• W2040861570 hasConcept C135763542 @default.
• W2040861570 hasConcept C153209595 @default.
• W2040861570 hasConcept C157410074 @default.
• W2040861570 hasConcept C180754005 @default.
• W2040861570 hasConcept C197754878 @default.
• W2040861570 hasConcept C2778163477 @default.
• W2040861570 hasConcept C2779422640 @default.
• W2040861570 hasConcept C2780578515 @default.
• W2040861570 hasConcept C2780586474 @default.
• W2040861570 hasConcept C2908647359 @default.
• W2040861570 hasConcept C37463918 @default.

• next