Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040871004> ?p ?o ?g. }
- W2040871004 endingPage "325" @default.
- W2040871004 startingPage "311" @default.
- W2040871004 abstract "In eukaryotic cells, protein biosynthesis is controlled at the level of polypeptide chain initiation. During the initiation process, eukaryotic initiation factor 2 (eIF-2) catalyzes the binding of Met-tRNAf and GTP to the 40S ribosomal subunit. In a later step, eIF-2 is released from the ribosomal initiation complex, most likely as an eIF-2.GDP complex, and another initiation factor termed eIF-2B is necessary to recycle eIF-2 by displacing GDP by GTP. In rabbit reticulocytes, inhibition of protein synthesis is accompanied by the phosphorylation of the alpha-subunit of eIF-2, a process that does not render eIF-2 inactive, but prevents it from being recycled by eIF-2B. First described in rabbit reticulocytes as inhibitors of translation, two distinct eIF-2 alpha kinases are known: the haemin-controlled kinase (termed HCI) and the double-stranded RNA-activated kinase (termed DAI). eIF-2 alpha phosphorylation appears to be a reversible control mechanism since corresponding phosphatases have been described. Recent reports indicate a correlation between eIF-2 alpha phosphorylation and the inhibition of protein synthesis in several mammalian cell types under a range of physiological conditions. In this review, the physical and functional features of the known eIF-2 alpha kinases are described with respect to their role in mammalian cells and the mode of activation by cellular signals. Furthermore, the possible impact of the eIF-2/eIF-2B ratio and of the subcellular compartmentation of these factors (and the eIF-2 alpha kinases) on mammalian protein synthesis is discussed." @default.
- W2040871004 created "2016-06-24" @default.
- W2040871004 creator A5066600273 @default.
- W2040871004 date "1989-01-01" @default.
- W2040871004 modified "2023-10-02" @default.
- W2040871004 title "The phosphorylation of eukaryotic initiation factor 2: A principle of translational control in mammalian cells" @default.
- W2040871004 cites W1480211327 @default.
- W2040871004 cites W1480450499 @default.
- W2040871004 cites W1483359701 @default.
- W2040871004 cites W1485381313 @default.
- W2040871004 cites W1488906799 @default.
- W2040871004 cites W1499458587 @default.
- W2040871004 cites W1501258699 @default.
- W2040871004 cites W1505080216 @default.
- W2040871004 cites W1506260722 @default.
- W2040871004 cites W1529554110 @default.
- W2040871004 cites W1531087684 @default.
- W2040871004 cites W1535827761 @default.
- W2040871004 cites W1537683572 @default.
- W2040871004 cites W1547921937 @default.
- W2040871004 cites W1553950927 @default.
- W2040871004 cites W1569310536 @default.
- W2040871004 cites W1574158932 @default.
- W2040871004 cites W1582095946 @default.
- W2040871004 cites W1582834666 @default.
- W2040871004 cites W1589355384 @default.
- W2040871004 cites W1593443523 @default.
- W2040871004 cites W1596444914 @default.
- W2040871004 cites W1597060371 @default.
- W2040871004 cites W1598799083 @default.
- W2040871004 cites W1600092335 @default.
- W2040871004 cites W1605422079 @default.
- W2040871004 cites W1677962389 @default.
- W2040871004 cites W1845690770 @default.
- W2040871004 cites W1877311823 @default.
- W2040871004 cites W1964229393 @default.
- W2040871004 cites W1964547053 @default.
- W2040871004 cites W1965177762 @default.
- W2040871004 cites W1968219959 @default.
- W2040871004 cites W1969683800 @default.
- W2040871004 cites W1973773971 @default.
- W2040871004 cites W1974409897 @default.
- W2040871004 cites W1979098463 @default.
- W2040871004 cites W1983150638 @default.
- W2040871004 cites W1987160102 @default.
- W2040871004 cites W1987444524 @default.
- W2040871004 cites W1987980067 @default.
- W2040871004 cites W1988219295 @default.
- W2040871004 cites W1989136432 @default.
- W2040871004 cites W1990439113 @default.
- W2040871004 cites W1997243576 @default.
- W2040871004 cites W2007122868 @default.
- W2040871004 cites W2013595376 @default.
- W2040871004 cites W2017321520 @default.
- W2040871004 cites W2026729363 @default.
- W2040871004 cites W2028723967 @default.
- W2040871004 cites W2031279518 @default.
- W2040871004 cites W2034548199 @default.
- W2040871004 cites W2037168957 @default.
- W2040871004 cites W2039027504 @default.
- W2040871004 cites W2039907166 @default.
- W2040871004 cites W2040109646 @default.
- W2040871004 cites W2042661553 @default.
- W2040871004 cites W2045466392 @default.
- W2040871004 cites W2048572361 @default.
- W2040871004 cites W2049099625 @default.
- W2040871004 cites W2049463632 @default.
- W2040871004 cites W2055413813 @default.
- W2040871004 cites W2060485988 @default.
- W2040871004 cites W2062417484 @default.
- W2040871004 cites W2063284585 @default.
- W2040871004 cites W2065276348 @default.
- W2040871004 cites W2075229081 @default.
- W2040871004 cites W2079220249 @default.
- W2040871004 cites W2082945210 @default.
- W2040871004 cites W2084653502 @default.
- W2040871004 cites W2086049995 @default.
- W2040871004 cites W2089424335 @default.
- W2040871004 cites W2089428849 @default.
- W2040871004 cites W2092755849 @default.
- W2040871004 cites W2093939878 @default.
- W2040871004 cites W2099674663 @default.
- W2040871004 cites W2103204666 @default.
- W2040871004 cites W2103832597 @default.
- W2040871004 cites W2154128645 @default.
- W2040871004 cites W2156638980 @default.
- W2040871004 cites W2201182020 @default.
- W2040871004 cites W2254141979 @default.
- W2040871004 cites W2412253612 @default.
- W2040871004 cites W2767361505 @default.
- W2040871004 cites W301540371 @default.
- W2040871004 cites W35623920 @default.
- W2040871004 cites W4232159746 @default.
- W2040871004 cites W4234654748 @default.
- W2040871004 cites W4244516852 @default.
- W2040871004 cites W4323254786 @default.
- W2040871004 doi "https://doi.org/10.1016/0303-2647(89)90053-1" @default.
- W2040871004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2679904" @default.