FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040873077> ?p ?o ?g. }

• W2040873077 abstract "We investigated the effects of age and nafidrofuryl oxalate (Naftidrofuryl), a 5-HT2 antagonist, on neurotransmission and transduction systems in the gerbil hippocampus using quantitative autoradiography. [3H]Quinuclidinyl benzilate (QNB), [3H]cyclohexyl-adenosine (CHA), [3H]MK-801, and [3H]muscimol were used to label muscarinic acetylcholine, adenosine A1, N-methyl-D-aspartate (NMDA), and gamma-aminobutyric acid-A (GABAA) receptors, respectively. [3H]PN200-110 labeled L-type Ca2+ channels. [3H]Forskolin, [3H]cyclic adenosine monophosphate (cAMP), [3H]phorbol 12,13-dibutyrate (PDBu), and [3H]inositol 1,4,5-triphosphate (IP3) were used to label adenylate cyclase, cAMP-dependent protein kinase, protein kinase C (PKC), and IP3 receptors, respectively. Approximately 20% reductions in [3H]QNB, [3H]forskolin, and [3H]PDBu binding were observed in the hippocampus of 9-month-old gerbils in comparison with 5-week-old gerbils. Treatment with Naftidrofuryl (10 mg/kg, i.p., once a day for 7 days) ameliorated these reductions. No changes were found in [3H]CHA, [3H]MK-801, [3H]muscimol, [3H]PN200-110, [3H]cAMP, and [3H]IP3 binding. The results suggest that Naftidrofuryl may have beneficial effects on the age-related alterations in signal transmission and transduction systems in the brain. Because the acetylcholine system, adenylate cyclase, and PKC are considered to be involved in learning and memory processes, the result may have clinical implications." @default.
• W2040873077 created "2016-06-24" @default.
• W2040873077 creator A5003969200 @default.
• W2040873077 creator A5038813552 @default.
• W2040873077 creator A5054408940 @default.
• W2040873077 creator A5055152100 @default.
• W2040873077 creator A5059583115 @default.
• W2040873077 creator A5080612002 @default.
• W2040873077 date "1994-05-01" @default.
• W2040873077 modified "2023-09-24" @default.
• W2040873077 title "Effects of naftidrofuryl oxalate, a 5HT2 antagonist, on neurotransmission and transduction systems in the gerbil hippocampus" @default.
• W2040873077 cites W1490844487 @default.
• W2040873077 cites W1964839077 @default.
• W2040873077 cites W1966360491 @default.
• W2040873077 cites W1970917461 @default.
• W2040873077 cites W1973688581 @default.
• W2040873077 cites W1978900411 @default.
• W2040873077 cites W1979020156 @default.
• W2040873077 cites W1979986714 @default.
• W2040873077 cites W1981784706 @default.
• W2040873077 cites W1986248068 @default.
• W2040873077 cites W2001692359 @default.
• W2040873077 cites W2011904317 @default.
• W2040873077 cites W2019556409 @default.
• W2040873077 cites W2027109102 @default.
• W2040873077 cites W2029770297 @default.
• W2040873077 cites W2032348825 @default.
• W2040873077 cites W2036979250 @default.
• W2040873077 cites W2037512229 @default.
• W2040873077 cites W2042854337 @default.
• W2040873077 cites W2049111961 @default.
• W2040873077 cites W2056550783 @default.
• W2040873077 cites W2060883530 @default.
• W2040873077 cites W2061403509 @default.
• W2040873077 cites W2065825417 @default.
• W2040873077 cites W2069284575 @default.
• W2040873077 cites W2069816656 @default.
• W2040873077 cites W2071377230 @default.
• W2040873077 cites W2073695258 @default.
• W2040873077 cites W2078908070 @default.
• W2040873077 cites W2080085773 @default.
• W2040873077 cites W2080909114 @default.
• W2040873077 cites W2095304409 @default.
• W2040873077 cites W2122888728 @default.
• W2040873077 cites W2154515069 @default.
• W2040873077 cites W2156263552 @default.
• W2040873077 cites W2285065435 @default.
• W2040873077 cites W2412222156 @default.
• W2040873077 cites W2413718792 @default.
• W2040873077 cites W2426937454 @default.
• W2040873077 cites W1736583473 @default.
• W2040873077 doi "https://doi.org/10.1016/0006-8993(94)90080-9" @default.
• W2040873077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8069666" @default.
• W2040873077 hasPublicationYear "1994" @default.
• W2040873077 type Work @default.
• W2040873077 sameAs 2040873077 @default.
• W2040873077 citedByCount "1" @default.
• W2040873077 crossrefType "journal-article" @default.
• W2040873077 hasAuthorship W2040873077A5003969200 @default.
• W2040873077 hasAuthorship W2040873077A5038813552 @default.
• W2040873077 hasAuthorship W2040873077A5054408940 @default.
• W2040873077 hasAuthorship W2040873077A5055152100 @default.
• W2040873077 hasAuthorship W2040873077A5059583115 @default.
• W2040873077 hasAuthorship W2040873077A5080612002 @default.
• W2040873077 hasConcept C126322002 @default.
• W2040873077 hasConcept C134018914 @default.
• W2040873077 hasConcept C170493617 @default.
• W2040873077 hasConcept C185592680 @default.
• W2040873077 hasConcept C195794163 @default.
• W2040873077 hasConcept C200170125 @default.
• W2040873077 hasConcept C2776991684 @default.
• W2040873077 hasConcept C2779276759 @default.
• W2040873077 hasConcept C55493867 @default.
• W2040873077 hasConcept C62478195 @default.
• W2040873077 hasConcept C71924100 @default.
• W2040873077 hasConcept C86803240 @default.
• W2040873077 hasConceptScore W2040873077C126322002 @default.
• W2040873077 hasConceptScore W2040873077C134018914 @default.
• W2040873077 hasConceptScore W2040873077C170493617 @default.
• W2040873077 hasConceptScore W2040873077C185592680 @default.
• W2040873077 hasConceptScore W2040873077C195794163 @default.
• W2040873077 hasConceptScore W2040873077C200170125 @default.
• W2040873077 hasConceptScore W2040873077C2776991684 @default.
• W2040873077 hasConceptScore W2040873077C2779276759 @default.
• W2040873077 hasConceptScore W2040873077C55493867 @default.
• W2040873077 hasConceptScore W2040873077C62478195 @default.
• W2040873077 hasConceptScore W2040873077C71924100 @default.
• W2040873077 hasConceptScore W2040873077C86803240 @default.
• W2040873077 hasLocation W20408730771 @default.
• W2040873077 hasLocation W20408730772 @default.
• W2040873077 hasOpenAccess W2040873077 @default.
• W2040873077 hasPrimaryLocation W20408730771 @default.
• W2040873077 hasRelatedWork W1992873995 @default.
• W2040873077 hasRelatedWork W2007885146 @default.
• W2040873077 hasRelatedWork W2009829090 @default.
• W2040873077 hasRelatedWork W2011584433 @default.
• W2040873077 hasRelatedWork W2057867440 @default.
• W2040873077 hasRelatedWork W2058991568 @default.
• W2040873077 hasRelatedWork W2062519124 @default.
• W2040873077 hasRelatedWork W2065224155 @default.

• next