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• W2040873625 abstract "Abstract Moloney cell surface antigen (MCSA) is serologically detectable on Moloney murine leukemia virus (Mo-MuLV)-induced lymphomas. It is probably related to the tumor-associated transplantation antigen of these lymphomas. We characterized MCSA by using the typing antiserum in radioimmunoprecipitations followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Surface-iodinated Mo-MuLV-infected cells were used to identify the molecular nature of MCSA. It appeared that MCSA was expressed as an entity of 82,000 apparent molecular weight (p82MCSA). Translation of size-fractionated mRNAs from infected cells in oocytes of Xenopus laevis showed that p82MCSA was made on an mRNA of the same size (22 S) as that coding for the Mo-MuLV env proteins. Moreover, p82MCSA was processed in oocytes to proteins exactly comigrating in the gel with gp70, p15E, and p12E. Competition experiments with unlabeled virus showed that MCSA and the MCSA-related env-like proteins made in oocytes were not related to any of the Mo-MuLV structural proteins. We concluded that MCSA has the properties of the product of the env gene of a murine C-type virus different from Mo-MuLV." @default.
• W2040873625 created "2016-06-24" @default.
• W2040873625 creator A5055449585 @default.
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• W2040873625 date "1981-04-01" @default.
• W2040873625 modified "2023-10-18" @default.
• W2040873625 title "Moloney cell surface antigen (MCSA) has properties of an env gene product that is serologically distinct from the env gene products of the moloney strain of murine leukemia virus" @default.
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• W2040873625 doi "https://doi.org/10.1016/0042-6822(81)90068-4" @default.
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