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- W2040880080 abstract "Summary: In 12 patients with primary hypertension (World Health Organization stage 2) inadequately controlled by chronic standard triple therapy, hydralazine was replaced by felodipine, a new vasodilating dihydropyridine derivative, and the acute effects of the drug on central and renal hemodynamics were monitored. Following baseline measurements, an oral solution of felodipine (0.075–0.1 mg/kg) was given. Fifteen minutes after intake of felodipine, a significant hypotensive response was observed, and the maximal response (23% reduction of mean arterial pressure) occurred after 30 min. There was a linear relationship between the changes in mean arterial pressure and log plasma concentration of felodipine. Cardiac output (dye dilution) increased during maximal blood pressure reduction, from 5.3 ± 1.0 to 6.6 ± 2.4 L/min (p < 0.01), partly because of increased heart rate from 57 ± 4 to 65 ± 9.1 beats/min (p < 0.01) and partly because of increased stroke volume from 93 ± 14 to 104 ± 33 ml (p < 0.05). Renal plasma flow (paraaminohippuric acid clearance) increased significantly (p < 0.05) from 343 ± 138 to 391 ± 154 ml/min, while glomerular filtration rate ([51Cr]EDTA clearance) did not change. Arteriovenous noradrenaline difference increased 36% during felodipine therapy, when corrected for blood flow increase. We conclude that felodipine is a calcium inhibitor with potent vasodilating properties." @default.
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- W2040880080 title "Systemic and Renal Hemodynamic Effects of Single Oral Doses of Felodipine in Patients with Refractory Hypertension Receiving Chronic Therapy with β-Blockers and Diuretics" @default.
- W2040880080 doi "https://doi.org/10.1097/00005344-198505000-00021" @default.
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