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- W2040881823 abstract "A growing body of evidence suggests that neural peptides may induce important modulations on vegative and motor functions of the eye. The present study was designed to evaluate the effect of intracameral (I.C.) administration of α-melanocyte-stimulating hormone (α-MSH) and several other ocular peptides on intraocular pressure (IOP) in rabbits. α-MSH (5 μg) produced a significant and prolonged unilateral increase of IOP. This efeect of I.C. α-MSH was dose-dependent (ED50 = 2.5 μg). Structure-activity studies revealed that equimolar doses of β-MSH and γ-MSH, unlike α-MSH, were totally ineffective. In addition, the structurally unrelated peptides β-endorphin, thyrotropin-releasing hormone (TRH) and gonadotropin-releasing hormone (Gn-RH) did not affect IOP, when tested in a dose equimolar to 5 μg of α-MSH. These results confirm and extend previous observations, suggesting that α-MSH may be an important factor involved in regulation of IOP." @default.
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- W2040881823 date "1985-12-01" @default.
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- W2040881823 title "Intracameral administration of α-MSH increases intraocular pressure in rabbits" @default.
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- W2040881823 doi "https://doi.org/10.1016/0143-4179(85)90118-0" @default.
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