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- W2040883987 abstract "1. The indirect negative inotropic effects of P1- and muscarinic-receptor agonists were compared by examining how the responses of isolated guinea-pig left atria and papillary muscles to positive inotropes were affected by the presence of the p1-receptor agonist, l-PIA or the muscarinic-receptor agonist, carbachol. 2. The indirect negative inotropic effects of l-PIA and carbachol were similar: both attenuated the responses of left atria more effectively than those of papillary muscles; and both more effectively attenuated responses to the cAMP-dependent positive inotropes, isoprenaline and forskolin. 3. However, there were differences: l-PIA, but not carbachol, was able at high concentrations to inhibit the responses of left atria to the calcium channel opener Bay K 8644; and at concentrations that produced similar direct negative inotropic effects, l-PIA consistently attenuated the positive inotropes more effectively than carbachol. 4. These findings are consistent with l-PIA being able to activate an additional negative inotropic mechanism that carbachol cannot." @default.
- W2040883987 created "2016-06-24" @default.
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- W2040883987 date "1992-07-01" @default.
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- W2040883987 title "The effects of P1- and muscarinic-receptor agonists upon cAMP-dependent and independent inotropic responses of guinea-pig cardiac preparations" @default.
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- W2040883987 doi "https://doi.org/10.1016/0306-3623(92)90137-9" @default.
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