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• W2040885081 abstract "A polypill for the primary prevention of cardiovascular disease has been proposed. We estimated the projected benefit of a secondary prevention poly-portfolio strategy, including pharmacologic and lifestyle approaches for those with coronary heart disease (CHD) or stroke. Based on recent clinical trial results and clinical guidelines, combinations of a high-dose statin, low to standard doses of antihypertensive therapy, aspirin, omega-3 fish oil, cardiac rehabilitation, and diet were evaluated. Patients with CHD, post-myocardial infarction (MI), or stroke were projected to experience 84%, 91%, and 77% reductions, respectively, in CHD events from a pharmacologic approach. Numbers of those needed to treat (NNT) for 5 years were 9 to 11 to prevent 1 CHD event, and 21 to prevent 1 stroke. Post-MI patients were projected to experience a 93% reduction in the risk of CHD death (NNT 16) from a pharmacologic approach and a 97% reduction in the risk of CHD death (NNT 15) with the addition of lifestyle changes. A secondary prevention polyportfolio holds great promise for reducing the burden of cardiovascular disease in the highest risk patients." @default.
• W2040885081 created "2016-06-24" @default.
• W2040885081 creator A5032509586 @default.
• W2040885081 creator A5089418361 @default.
• W2040885081 date "2005-02-01" @default.
• W2040885081 modified "2023-09-27" @default.
• W2040885081 title "A “poly-portfolio” for secondary prevention: A strategy to reduce subsequent events by up to 97% over five years" @default.
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• W2040885081 doi "https://doi.org/10.1016/j.amjcard.2004.09.036" @default.
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