Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040886088> ?p ?o ?g. }
- W2040886088 endingPage "1009" @default.
- W2040886088 startingPage "1000" @default.
- W2040886088 abstract "Protein modification by ADP-ribose polymers is a common regulatory mechanism in eukaryotic cells and is involved in several aspects of brain physiology and physiopathology, including neurotransmission, memory formation, neurotoxicity, ageing and age-associated diseases. Here we show age-related misregulation of poly(ADP-ribose) synthesis in rat cerebellum as revealed by: (i) reduced poly(ADP-ribose) polymerase-1 (PARP-1) activation in response to enzymatic DNA cleavage, (ii) altered protein poly(ADP-ribosyl)ation profiles in isolated nuclei, and (iii) cell type-specific loss of poly(ADP-ribosyl)ation capacity in granule cell layer and Purkinje cells in vivo. In particular, although PARP-1 could be detected in virtually all granule cells, only a fraction of them appeared to be actively engaged in poly(ADP-ribose) synthesis and this fraction was reduced in old rat cerebellum. NAD+, quantified in tissue homogenates, was essentially the same in the cerebellum of young and old rats suggesting that in vivo factors other than PARP-1 content and/or NAD+ levels may be responsible for the age-associated lowering of poly(ADP-ribose) synthesis. Moreover, PARP-1 expression was substantially down-regulated in Purkinje cells of senescent rats." @default.
- W2040886088 created "2016-06-24" @default.
- W2040886088 creator A5011530387 @default.
- W2040886088 creator A5020059553 @default.
- W2040886088 creator A5025879472 @default.
- W2040886088 creator A5054589020 @default.
- W2040886088 creator A5070965521 @default.
- W2040886088 creator A5086629751 @default.
- W2040886088 creator A5087716856 @default.
- W2040886088 creator A5088202869 @default.
- W2040886088 date "2005-05-01" @default.
- W2040886088 modified "2023-10-17" @default.
- W2040886088 title "Misregulation of poly(ADP-ribose) polymerase-1 activity and cell type-specific loss of poly(ADP-ribose) synthesis in the cerebellum of aged rats" @default.
- W2040886088 cites W112848905 @default.
- W2040886088 cites W1409190662 @default.
- W2040886088 cites W1541618811 @default.
- W2040886088 cites W1543701118 @default.
- W2040886088 cites W1775749144 @default.
- W2040886088 cites W1844286590 @default.
- W2040886088 cites W1906197854 @default.
- W2040886088 cites W1965207643 @default.
- W2040886088 cites W1966645907 @default.
- W2040886088 cites W1967488625 @default.
- W2040886088 cites W1973188488 @default.
- W2040886088 cites W1980647462 @default.
- W2040886088 cites W1981024134 @default.
- W2040886088 cites W1992476369 @default.
- W2040886088 cites W1993972255 @default.
- W2040886088 cites W1994011134 @default.
- W2040886088 cites W1996896491 @default.
- W2040886088 cites W1997973656 @default.
- W2040886088 cites W2004103693 @default.
- W2040886088 cites W2004808899 @default.
- W2040886088 cites W2005706069 @default.
- W2040886088 cites W2006942905 @default.
- W2040886088 cites W2009567717 @default.
- W2040886088 cites W2010016694 @default.
- W2040886088 cites W2010873407 @default.
- W2040886088 cites W2011628041 @default.
- W2040886088 cites W2012242260 @default.
- W2040886088 cites W2012759361 @default.
- W2040886088 cites W2014150894 @default.
- W2040886088 cites W2014300705 @default.
- W2040886088 cites W2018016625 @default.
- W2040886088 cites W2021643429 @default.
- W2040886088 cites W2022353228 @default.
- W2040886088 cites W2022623686 @default.
- W2040886088 cites W2022781542 @default.
- W2040886088 cites W2024876727 @default.
- W2040886088 cites W2027537529 @default.
- W2040886088 cites W2027968455 @default.
- W2040886088 cites W2032552530 @default.
- W2040886088 cites W2033761616 @default.
- W2040886088 cites W2036265947 @default.
- W2040886088 cites W2036950607 @default.
- W2040886088 cites W2037794801 @default.
- W2040886088 cites W2042222447 @default.
- W2040886088 cites W2052495978 @default.
- W2040886088 cites W2057706543 @default.
- W2040886088 cites W2059728534 @default.
- W2040886088 cites W2063413535 @default.
- W2040886088 cites W2073373002 @default.
- W2040886088 cites W2075322420 @default.
- W2040886088 cites W2080234910 @default.
- W2040886088 cites W2080939094 @default.
- W2040886088 cites W2083810864 @default.
- W2040886088 cites W2084060660 @default.
- W2040886088 cites W2086364659 @default.
- W2040886088 cites W2096706830 @default.
- W2040886088 cites W2100837269 @default.
- W2040886088 cites W2106390123 @default.
- W2040886088 cites W2111614709 @default.
- W2040886088 cites W2115071469 @default.
- W2040886088 cites W2117062102 @default.
- W2040886088 cites W2125628261 @default.
- W2040886088 cites W2132412147 @default.
- W2040886088 cites W2132517957 @default.
- W2040886088 cites W2133469432 @default.
- W2040886088 cites W2148493751 @default.
- W2040886088 cites W2151861142 @default.
- W2040886088 cites W2163969081 @default.
- W2040886088 cites W2164091821 @default.
- W2040886088 cites W4247607816 @default.
- W2040886088 cites W4318442930 @default.
- W2040886088 cites W654533257 @default.
- W2040886088 cites W99053401 @default.
- W2040886088 doi "https://doi.org/10.1111/j.1471-4159.2005.03082.x" @default.
- W2040886088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15857403" @default.
- W2040886088 hasPublicationYear "2005" @default.
- W2040886088 type Work @default.
- W2040886088 sameAs 2040886088 @default.
- W2040886088 citedByCount "6" @default.
- W2040886088 countsByYear W20408860882017 @default.
- W2040886088 crossrefType "journal-article" @default.
- W2040886088 hasAuthorship W2040886088A5011530387 @default.
- W2040886088 hasAuthorship W2040886088A5020059553 @default.
- W2040886088 hasAuthorship W2040886088A5025879472 @default.
- W2040886088 hasAuthorship W2040886088A5054589020 @default.