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- W2040886514 abstract "We synthesized and evaluated new specific tridentate iron(III) chelators of 2,6-bis[hydroxyamino]-1,3,5-triazine (BHT) family for use in iron deprivation cancer therapy. Physical properties of BHT chelators are easily customizable allowing easy penetration through cellular membranes. Antiproliferative activity of new BHT chelators was studied on MDA-MB-231 and MiaPaCa cells and compared to a clinically available new oral iron chelator, deferasirox (DFX). The antiproliferative activity of new chelators was found to correlate with iron(III) chelation ability and some of analogs showed substantially higher antiproliferative activity than DFX." @default.
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- W2040886514 date "2010-01-01" @default.
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- W2040886514 title "Synthesis and antiproliferating activity of iron chelators of hydroxyamino-1,3,5-triazine family" @default.
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- W2040886514 doi "https://doi.org/10.1016/j.bmcl.2009.11.130" @default.
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