FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040886821> ?p ?o ?g. }

• W2040886821 endingPage "2048" @default.
• W2040886821 startingPage "2043" @default.
• W2040886821 abstract "Liver toxicity caused by high-dose myeloablative therapy leads to significant morbidity after hematopoietic cell transplantation. We examined the hypothesis that liver toxicity after cyclophosphamide and total body irradiation is related to cyclophosphamide through its metabolism to toxins. Cyclophosphamide was infused at 60 mg/kg over 1 to 2 hours on each of 2 consecutive days, followed by total body irradiation. Plasma was analyzed for cyclophosphamide and its major metabolites. Liver toxicity was scored by the development of sinusoidal obstruction syndrome (veno-occlusive disease) and by total serum bilirubin levels. The hazards of liver toxicity, nonrelapse mortality, tumor relapse, and survival were calculated using regression analysis that included exposure to cyclophosphamide metabolites (as the area under the curve). Of 147 patients, 23 (16%) developed moderate or severe sinusoidal obstruction syndrome. The median peak serum bilirubin level through day 20 was 2.6 mg/dL (range, 0.5-41.1 mg/dL). Metabolism of cyclophosphamide was highly variable, particularly for the metaboliteo-carboxyethyl-phosphoramide mustard, whose area under the curve varied 16-fold. Exposure to this metabolite was statistically significantly related to sinusoidal obstruction syndrome, bilirubin elevation, nonrelapse mortality, and survival, after adjusting for age and irradiation dose. Patients in the highest quartile ofo-carboxyethyl-phosphoramide mustard exposure had a 5.9-fold higher risk for nonrelapse mortality than did patients in the lowest quartile. Engraftment and tumor relapse were not statistically significantly related to cyclophosphamide metabolite exposure. Increased exposure to toxic metabolites of cyclophosphamide leads to increased liver toxicity and nonrelapse mortality and lower overall survival after hematopoietic cell transplantation." @default.
• W2040886821 created "2016-06-24" @default.
• W2040886821 creator A5003934427 @default.
• W2040886821 creator A5016464302 @default.
• W2040886821 creator A5023949296 @default.
• W2040886821 creator A5032915645 @default.
• W2040886821 creator A5059001915 @default.
• W2040886821 creator A5060783496 @default.
• W2040886821 creator A5062695456 @default.
• W2040886821 creator A5089016512 @default.
• W2040886821 creator A5089743415 @default.
• W2040886821 date "2003-03-01" @default.
• W2040886821 modified "2023-10-02" @default.
• W2040886821 title "Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation" @default.
• W2040886821 cites W1963661801 @default.
• W2040886821 cites W1966771497 @default.
• W2040886821 cites W1972172571 @default.
• W2040886821 cites W1989362562 @default.
• W2040886821 cites W1991764274 @default.
• W2040886821 cites W1992248095 @default.
• W2040886821 cites W2006201383 @default.
• W2040886821 cites W2012021913 @default.
• W2040886821 cites W2018714108 @default.
• W2040886821 cites W2025383600 @default.
• W2040886821 cites W2026710725 @default.
• W2040886821 cites W2038235266 @default.
• W2040886821 cites W2041968020 @default.
• W2040886821 cites W2067209713 @default.
• W2040886821 cites W2069099341 @default.
• W2040886821 cites W2073790391 @default.
• W2040886821 cites W2076404680 @default.
• W2040886821 cites W2076894256 @default.
• W2040886821 cites W2080355683 @default.
• W2040886821 cites W2115587276 @default.
• W2040886821 cites W2122712927 @default.
• W2040886821 cites W2140690834 @default.
• W2040886821 cites W2168847627 @default.
• W2040886821 cites W2276362528 @default.
• W2040886821 cites W4251368259 @default.
• W2040886821 cites W4299475157 @default.
• W2040886821 doi "https://doi.org/10.1182/blood-2002-06-1860" @default.
• W2040886821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12406916" @default.
• W2040886821 hasPublicationYear "2003" @default.
• W2040886821 type Work @default.
• W2040886821 sameAs 2040886821 @default.
• W2040886821 citedByCount "323" @default.
• W2040886821 countsByYear W20408868212012 @default.
• W2040886821 countsByYear W20408868212013 @default.
• W2040886821 countsByYear W20408868212014 @default.
• W2040886821 countsByYear W20408868212015 @default.
• W2040886821 countsByYear W20408868212016 @default.
• W2040886821 countsByYear W20408868212017 @default.
• W2040886821 countsByYear W20408868212018 @default.
• W2040886821 countsByYear W20408868212019 @default.
• W2040886821 countsByYear W20408868212020 @default.
• W2040886821 countsByYear W20408868212021 @default.
• W2040886821 countsByYear W20408868212022 @default.
• W2040886821 countsByYear W20408868212023 @default.
• W2040886821 crossrefType "journal-article" @default.
• W2040886821 hasAuthorship W2040886821A5003934427 @default.
• W2040886821 hasAuthorship W2040886821A5016464302 @default.
• W2040886821 hasAuthorship W2040886821A5023949296 @default.
• W2040886821 hasAuthorship W2040886821A5032915645 @default.
• W2040886821 hasAuthorship W2040886821A5059001915 @default.
• W2040886821 hasAuthorship W2040886821A5060783496 @default.
• W2040886821 hasAuthorship W2040886821A5062695456 @default.
• W2040886821 hasAuthorship W2040886821A5089016512 @default.
• W2040886821 hasAuthorship W2040886821A5089743415 @default.
• W2040886821 hasBestOaLocation W20408868211 @default.
• W2040886821 hasConcept C126322002 @default.
• W2040886821 hasConcept C2776694085 @default.
• W2040886821 hasConcept C2776755627 @default.
• W2040886821 hasConcept C2777408962 @default.
• W2040886821 hasConcept C2777477808 @default.
• W2040886821 hasConcept C2777513400 @default.
• W2040886821 hasConcept C2778880498 @default.
• W2040886821 hasConcept C2780895475 @default.
• W2040886821 hasConcept C2911091166 @default.
• W2040886821 hasConcept C29730261 @default.
• W2040886821 hasConcept C71924100 @default.
• W2040886821 hasConcept C90924648 @default.
• W2040886821 hasConceptScore W2040886821C126322002 @default.
• W2040886821 hasConceptScore W2040886821C2776694085 @default.
• W2040886821 hasConceptScore W2040886821C2776755627 @default.
• W2040886821 hasConceptScore W2040886821C2777408962 @default.
• W2040886821 hasConceptScore W2040886821C2777477808 @default.
• W2040886821 hasConceptScore W2040886821C2777513400 @default.
• W2040886821 hasConceptScore W2040886821C2778880498 @default.
• W2040886821 hasConceptScore W2040886821C2780895475 @default.
• W2040886821 hasConceptScore W2040886821C2911091166 @default.
• W2040886821 hasConceptScore W2040886821C29730261 @default.
• W2040886821 hasConceptScore W2040886821C71924100 @default.
• W2040886821 hasConceptScore W2040886821C90924648 @default.
• W2040886821 hasIssue "5" @default.
• W2040886821 hasLocation W20408868211 @default.
• W2040886821 hasOpenAccess W2040886821 @default.
• W2040886821 hasPrimaryLocation W20408868211 @default.
• W2040886821 hasRelatedWork W1977112375 @default.

• next