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• W2040887230 abstract "Neuropathic pain is caused by long-term modifications of neuronal function in the peripheral nervous system, the spinal cord, and supraspinal areas. Although functional changes in the forebrain are thought to contribute to the development of persistent pain, their significance and precise subcellular nature remain unexplored. Using somatic and dendritic whole-cell patch-clamp recordings from neurons in the anterior cingulate cortex, we discovered that sciatic nerve injury caused an activity-dependent dysfunction of hyperpolarization-activated cyclic nucleotide-regulated (HCN) channels in the dendrites of layer 5 pyramidal neurons resulting in enhanced integration of excitatory postsynaptic inputs and increased neuronal firing. Specific activation of the serotonin receptor type 7 (5-HT7R) alleviated the lesion-induced pathology by increasing HCN channel function, restoring normal dendritic integration, and reducing mechanical pain hypersensitivity in nerve-injured animals in vivo. Thus, serotoninergic neuromodulation at the forebrain level can reverse the dendritic dysfunction induced by neuropathic pain and may represent a potential therapeutical target." @default.
• W2040887230 created "2016-06-24" @default.
• W2040887230 creator A5051574691 @default.
• W2040887230 creator A5077686493 @default.
• W2040887230 date "2015-04-01" @default.
• W2040887230 modified "2023-10-14" @default.
• W2040887230 title "Dysfunction of Cortical Dendritic Integration in Neuropathic Pain Reversed by Serotoninergic Neuromodulation" @default.
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• W2040887230 cites W1793983851 @default.
• W2040887230 cites W192380281 @default.
• W2040887230 cites W1965066118 @default.
• W2040887230 cites W1966351672 @default.
• W2040887230 cites W1966819687 @default.
• W2040887230 cites W1967324141 @default.
• W2040887230 cites W1970125541 @default.
• W2040887230 cites W1972814213 @default.
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• W2040887230 cites W2069294743 @default.
• W2040887230 cites W2069918422 @default.
• W2040887230 cites W2071848914 @default.
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• W2040887230 doi "https://doi.org/10.1016/j.neuron.2015.03.003" @default.
• W2040887230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25819610" @default.
• W2040887230 hasPublicationYear "2015" @default.
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